Results 81 to 90 of about 10,020,504 (351)

Sealing performances of polymer heat-shrinkable tubing for deep rocks under high-temperature and ultrahigh-pressure condition

Journal of Rock Mechanics and Geotechnical Engineering
The deep underground engineering will face high-temperature and ultrahigh-pressure (HTUP) condition. Indoor triaxial testing is an important means to investigate this challenge in rock mechanics and rock engineering.
Heng Gao, Heping Xie, Zetian Zhang, Ru Zhang, Mingzhong Gao, Yihang Li, Ling Chen, Hongxin Xie   +7 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Double-targeted liposomes coated with matrix metallopeptidase-2-responsive polypeptide nanogel for chemotherapy and enhanced immunotherapy against cervical cancer

Materials Today Bio
Immunotherapy is a cornerstone in cancer treatment, celebrated for its precision, ability to eliminate residual cancer cells, and potential to avert tumor recurrence. Nonetheless, its effectiveness is frequently undermined by the immunosuppressive milieu
Zhimin Bai, Yibo Yang, Zutong Cui, Wenming Liang, Xin Zhang, Zihan Zhang, Jianming Sun, Zhiwei Liu, Kun Li, Ming Shi, Jian Li   +10 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysis of Bottom Reverberation Intensity Under Beam-Controlled Emission Conditions in Deep Water

Archives of Acoustics
A comprehensive understanding of the characteristics and the formation mechanism of reverberation is the key to improving the performance of the active target detection.
Guangying ZHENG, Xiaowei GUO, Fangwei ZHU, Fangyong WANG, Linlang BAI   +4 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A Performance Comparison Study on Climate Prediction in Weifang City Using Different Deep Learning Models

Water
Climate change affects the water cycle, water resource management, and sustainable socio-economic development. In order to accurately predict climate change in Weifang City, China, this study utilizes multiple data-driven deep learning models.
Qingchun Guo, Zhenfang He, Zhaosheng Wang, Shuaisen Qiao, Jingshu Zhu, Jiaxin Chen   +5 more
semanticscholar   +1 more source

Deep learning identifies accurate burst locations in water distribution networks.

Water Research, 2019
Pipe bursts in water distribution networks lead to considerable water loss and pose risks of bacteria and pollutant contamination. Pipe burst localisation methods help water service providers repair the burst pipes and restore water supply timely and ...
Xiao Zhou, Zhenheng Tang, Weirong Xu, Fanlin Meng, X. Chu, K. Xin, G. Fu   +6 more
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source