Results 91 to 100 of about 10,020,504 (351)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Ground-water and surface-water-level data at Rindge Tract on the Stockton Deep Water Ship Channel, San Joaquin County, California, 1983-84 [PDF]

, 1986
Michael Pierce, Karen Johnson
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental and simulation studies on damage characteristics, crack development patterns, and strength reduction mechanisms of sandstone under laser irradiation

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In order to explore the damage characteristics and crack development laws of hard rock under laser irradiation, laser irradiation experiments on sandstone were conducted considering the interaction of three laser parameters: spot diameter, laser power ...
Junjun Liu, Chuo Zhang, Lei Yang, Xuemin Zhou, Jing Xie, Bengao Yang, Zhiqiang He, Mingzhong Gao   +7 more
doaj   +1 more source

An Improved Artificial Electric Field Algorithm for Determining the Maximum Length of Gravel Packing in Deep-Water Horizontal Well

Journal of Marine Science and Engineering
Gravel packing in deep-water horizontal wells is an effective and practical sand control method, which is a key technical method to ensure efficient exploitation of deep-water oil and gas. To ensure the successful implementation of gravel packing in deep
Lei Yang, Hong Lin, Shengtian Zhou, Ziyue Feng   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Water–Gas Shift Reaction Produces Formate at Extreme Pressures and Temperatures in Deep Earth Fluids

, 2021
Nore Stolte, Junting Yu, Zixin Chen, Dimitri A. Sverjensky, Ding Pan   +4 more
openalex   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Deep-water prawn Pandalus borealis displays a relatively high pH regulatory capacity in response to CO2-induced acidosis [PDF]

, 2013
KM Hammer, Sindre Andre Pedersen
openalex   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source