Results 271 to 280 of about 716,083 (340)

The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health. [PDF]

Biology (Basel)
Azarias FR, Almeida GHDR, de Melo LF, Rici REG, Maria DA.   +4 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Machine Learning-Based Alexithymia Assessment Using Resting-State Default Mode Network Functional Connectivity. [PDF]

Sensors (Basel)
Suzuki K, Sugaya M.
europepmc   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Default mode network and visual network responsiveness to transcutaneous auricular vagus nerve stimulation predict its variable efficacy in primary insomnia disorder. [PDF]

Front Neurol
Wu X, Duan H, Wang Y, She S, Hu Y, He B.
europepmc   +1 more source

AI‐Directed 3D Printing of Hierarchical Polyurethane Foams

Advanced Science, EarlyView.
Digitally guided direct ink writing, combined with AI‐generated design, enables the fabrication of hierarchical polyurethane foams with tunable multiscale porosity. This approach produces architected foams featuring interconnected open‐cell networks and tailored mechanical properties, advancing the development of adaptive, high‐performance materials ...
Dhanush Patil, Jie Tian, Kun Jiang, Clarissa Westover, Sri Vaishnavi Thummalapalli, Arunachalam Ramanathan, Arpita Shome, Natalie Crutchfield, M. Taylor Sobczak, Sean Lee, Hongyue Sun, Elizabeth J. Brisbois, Hitesh Handa, Timothy E. Long, Xianqiao Wang, Kenan Song   +15 more
wiley   +1 more source

Cortical morphology changes in default mode network regions as predictors of cognitive decline in relation to amyloid and tau deposits. [PDF]

Brain Commun
Menardi A, Saglam C, La Rocca B, Cecchin D, Venneri A, Cagnin A, Vallesi A.   +6 more
europepmc   +1 more source