Advanced Science, EarlyView.MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia +4 more
wiley +1 more source
Are Corporate Default Probabilities Consistent with the Static Tradeoff Theory? [PDF]
Default probability plays a central role in the static tradeoff theory of capital structure. We directly test this theory by regressing the probability of default on proxies for costs and benefits of debt.
Armen Hovakimian +2 more
core
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Performance of cardiovascular disease risk prediction tools in chronic obstructive pulmonary disease. [PDF]
Ann Am Thorac SocSalimian S +4 more
europepmc +1 more source
Proceso de ASC - PREDICTING COLOMBIAN SOVEREIGN DEFAULT PROBABILITY USING MACHINE LEARNING
El propósito de esta investigación es utilizar una muestra para predecir la probabilidad de default del gobierno colombiano, mediante técnicas de machine learning que buscan crear algoritmos de predicción.
Galeano, Juan +3 more
core
What "triggers" mortgage default? [PDF]
This paper assesses the relative importance of two key drivers of mortgage default: negative equity and illiquidity. To do so, the authors combine loan-level mortgage data with detailed credit bureau information about the borrower's broader balance sheet.
Robert Hunt +5 more
core
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Assessment of Default Risk on Indonesian Corporate Sukuk Using the Moody’s KMV Model
Indonesian Interdisciplinary Journal of Sharia EconomicsThis study examines the probability of default of Corporate Sukuk issuers in Indonesia using the Moody's KMV Model. The increasing development of corporate sukuk in Indonesia has raised concerns regarding issuer solvency and default vulnerability ...
Mukhamad Ali Yusuf +2 more
doaj
Tree-Based Machine Learning for Diagnostic Classification of Dengue Fever Using Routine Hematological Parameters: A Secondary Analysis of a Publicly Available Dataset. [PDF]
Diagnostics (Basel)Yilmaz ZB, Kucukakcali Z, Akbulut S.
europepmc +1 more source
The Determinants of Attitudes towards Strategic Default on Mortgages [PDF]
We use survey data to study American households' propensity to default when the value of their mortgage exceeds the value of their house even if they can afford to pay their mortgage (strategic default).
Luigi Guiso +2 more
core