Results 111 to 120 of about 677,450 (332)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Fomoznoe defeat potatoes

open access: yesRUDN Journal of Agronomy and Animal Industries, 2014
Drawn attention to the increasing danger and harmfulness phomosis disease of potatoes, potatoes with lesions which may reduce its yield by 30-50%. A description of the signs of the disease in the form of ulceration and necrosis on tubers and diffuse ...
A A Kuzmichev, S V Maltsev, V N Zeyruk
doaj   +1 more source

Join Up, Scale Up: How Integration Can Defeat Disease and Poverty [PDF]

open access: yes, 2011
This report addresses three of the core areas: primary healthcare, clean water and sanitation, and nutrition -- that are essential to achieving the MDGs. It highlights examples across 17 countries of how bringing different development approaches together

core  

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

DEFEATING PHENOMENAL CONSERVATISM [PDF]

open access: yesPhilosophical Books, 2011
According to the phenomenal conservatives, beliefs are justified by nondoxastic states we might speak of as ‘appearances’ or ‘seemings.’ Those who defend the view say that there is something self-defeating about believing that phenomenal conservatism is mistaken. They also claim that the view captures an important internalist insight about justification.
openaire   +2 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

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