A comparative assessment of the antidepressant efficacy of ketamine, psilocybin, and fluoxetine in a chronic stress model. [PDF]
Sci RepDomżalska M +3 more
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Understanding the relationship between suicide-related stigma and suicidal thoughts through the lens of the Integrated Motivational-Volitional (IMV) model of suicide. [PDF]
BMC PsychiatryWyllie JM, Robb KA, O'Connor RC.
europepmc +1 more source
Destiny 2 Glitch Lets Players Defeat Raid Boss Before Fight Starts
, 2021 nad hellton
openalex +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Propranolol Administration During Morphine Addiction Attenuates Reinstatement of Drug-Aversive Memories Caused by Exposure to Stressful Stimuli. [PDF]
Pharmaceuticals (Basel)Cánovas-Cabanes A +5 more
europepmc +1 more source
The Nineteenth Amendment as a Generative Tool for Defeating LGBT Religious Exemptions [PDF]
, 2021 Kyle Velte
openalex
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Can multi-species biofilms defeat antimicrobial surfaces on medical devices?
, 2022 Madeleine Ramstedt, Mette Burmølle
openalex +1 more source