Results 101 to 110 of about 177,017,596 (221)

Caribbean Report 03-04-1995

, 1995
Dominica's Prime Minister Dame Eugenia Charles vows to stay on the campaign trail despite a stone throwing incident. The Washington Post takes the Clinton Administration to task over its conflicting policies toward Cuba. The United States is taking steps
Crosskill, Hugh (anchor), Sobers, Garfield (interviewee), Collymore, Yvette (correspondent), The British Broadcasting Corporation, Roberts, Andy (interviewee), Richards, Ken (correspondent), Niles, Bertram (correspondent)   +6 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Victory ‘dustlessly’ - victory by a clear advantage

RUDN Journal of World History
The purpose of the study is to find out the reasons why athletes at the Panhellenic and local games were awarded victory ‘dustlessly’ (ἀκονιτί), an undisputed, unqualified victory.
Tatiana B. Gvozdeva
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

PRIVATE METHOD OF CONSTRUCTION AND SYSTEM PASSING TO RADIO-LOCATION INFORMATION AFTER CRITERION OF FUNCTIONAL STABILITY ON BASE ALGORITHM PRIMA

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015
The article is devoted a construction functionally to the steady system and passing to radio-location information. It is suggested to carry out providing of functional stability due to introduction and surplus between the structural elements of the ...
Volodymyr V. Kireienko, Oleh V. Barabash
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Preferential opponent selection in public goods games [PDF]

, 2012
This paper discusses preferential opponent selection in public goods games. It is shown that a preference to play with successful opponents strongly enhances the prevalence of cooperation. The finding is robust on spatial grids and heterogeneous networks.
Brede, Markus
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Creating an Artificial Opponent for the Game Minotaurus

A.I. opponents have been a fixture of electronic games since the 1950’s. Over the course of the 20th and 21st centuries the technology has evolved to the computer opponents we know today.
Bielski, William
core   +1 more source