Results 81 to 90 of about 177,017,596 (221)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
IMPROVED METHOD OF DETERMINATION OF PRIORITY OF DEFEAT ROCKET OBJECTS OPPONENT FOR -AVIATION INFLICTINGS BLOWS IN THE OPERATIONS (BATTLE ACTIONS) OF MILITARY FORCES OF UKRAINE [PDF]
, 2014 Запропоновано методику визначення пріоритетності об’єктів ураження противника для нанесення ракетно-авіаційних ударів в операціях (бойових діях) Збройних Сил України.Предложена методика определения приоритетности объектов поражения противника для ...
В.В. Гамора, В.В. Gamora
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Emine Pehlivan: The Turkish Woman Who Defeated Male Opponents in Wrestling in the 1930s
Akademik Tarih ve Dusunce DergisiThis study explores the biography of Emine Pehlivan, a woman who lived in the Republic of Turkey in the 1930s and was actively engaged in the sport of wrestling and famous for competing against male opponents. She was a heavyweight wrestler known for her invincibility. The investigation of her wrestling career is important because it demonstrates that
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
An Underlying Model for Defeat Mechanisms
, 2000 Defeat mechanisms are strategies for achieving victory over an opponent. Although defeat mechanisms often rely on influencing the opponent psychologically and emotionally, most simulations of warfare do not model these "soft " factors, they ...
Paul R. Cohen, Brent Heeringa
core
About a defeat of the Centaurs, and how to imagine such an event in Olympia
, 2019 This posting, written 2019.04.19, picks up from where I left off in Classical Inquiries 2019.03.22, rewritten 2019.04.17. In the last paragraph of that posting, I focused on a myth that told about a defeat of the Centaurs, beastly hominoids who were half
Nagy, Gregory
core +4 more sources
The War of Narratives: The Clash Between the Discourses of Defense and Aggression in Gaza [PDF]
علوم سیاسیThe Al-Aqsa Flood operation (October 7, 2023) marked a major turning point in the long-standing conflict between the Palestinian resistance movement and the Zionist occupying regime, ushering the Arab-Israeli military confrontation into a new phase.
Abdulqaium Sajjadi
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source