Results 71 to 80 of about 177,017,596 (221)

Design of purpose of operation at planning of fire defeat of objects opponent in the modern terms of conduct the armed fight [PDF]

, 2009
На основі аналізу сучасних поглядів на ведення збройної боротьби визначена концепція системного аналізу оперативного простору, яку доцільно покласти в основу досліджень щодо вогневого ураження об’єктів противника.
В.М. Бильчук, A.A. Adamenko, В.М. Більчук, А.А. Адаменко, B.M.. Bil'chuk   +4 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland

, 2010
Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation and chronically by protein synthesis.
Lin Kooi Ong, Ong, Lin Kooi, Peter R. Dunkley, Dickson, Phillip W., Bobrovskaya, Larisa, Walker, Frederick R., Day, Trevor A., Dunkley, Peter R., Phillip W. Dickson, Frederick R. Walker, Trevor A. Day, Larisa Bobrovskaya   +11 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exercises to improve the effectiveness of Tokui-Waza in Tachi Waza/Ejercicios para mejorar la efectividad del Tokui-Waza en el Tachi Waza

Podium, 2021
In the current sport of Judo, the mastery of the Tokui-Waza or favorite technique is essential to defeat the opponent and win the victory, however this requires an adequate technical-tactical preparation and its systematization in the training process ...
Teobaldo Martínez Perdomo, Lázaro Alberto Pastor Chirino, Osviel Hernández Sotolongo, Rosa María Tabares Arevalo, Esteban Eddy Méndes Lazo   +4 more
doaj  

The treatment of defeated opponents in England, 1455–71

Historical Research
Abstract This article considers the treatment of defeated opponents between the First Battle of St Albans (1455) and the Battle of Tewkesbury (1471). It demonstrates that the Battle of Wakefield (1460) marked an increase in post-battle executions.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Learning to Model Opponent Learning (Student Abstract)

, 2020
Multi-Agent Reinforcement Learning (MARL) considers settings in which a set of coexisting agents interact with one another and their environment. The adaptation and learning of other agents induces non-stationarity in the environment dynamics. This poses
Tian, Zheng, Davies, Ian, Wang, Jun
core   +1 more source

The Influence of strategic culture on shaping security policy

Security and Defence Quarterly, 2019
Objectives The aim of the article is to present the role that strategic culture plays in creating and shaping security of the future. Taking account of the purpose of this paper, the main research problem took the form of the following question: To what
Adrian Mitręga, Marian Kozub
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source