Results 51 to 60 of about 142,095 (261)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Polarity switching via defect engineering in Cu doped SnSe0.75S0.25 solid solution for mid-temperature thermoelectric applications

Materials Research Express, 2023
Solid solution SnSe _0.75 S _0.25 has potential to improve thermoelectric performance via ultra-low thermal conductivity as compared to the pristine SnSe which originates from phonon scattering due to disordered atoms of selenium (Se) and sulfur (S ...
S Athithya, K P Mohamed Jibri, S Harish, K Hayakawa, Y Kubota, H Ikeda, Y Hayakawa, Y Inatomi, M Navaneethan, J Archana   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Defect engineering based on lattice plane oriented growth in Ru-Ceria system for photo-thermal catalytic methane dry reforming

Carbon Neutrality
Defect engineering provides a promising strategy to design efficient photo-thermal catalysts for methane dry reforming reaction, addressing challenges of harsh reaction conditions, and ultimately achieve the reduction of carbon footprint.
Zhen-Yu Zhang, Dong-Meng Su, Rui-Tao Li, Cong-Ying Feng, Lei Luo, Gui-Dong Yang, Tao Xie   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Reversible defect engineering in graphene grain boundaries

Nature Communications, 2019
Engineering the grain boundary size of chemical vapor deposited monolayer graphene can reversibly tune its electronic properties. Here, the authors report a thermodynamic correlation for 100 μm long channels in graphene by reversibly changing its ...
Krishna Balasubramanian, Tathagatha Biswas, Priyadarshini Ghosh, Swathi Suran, Abhishek Mishra, Rohan Mishra, Ritesh Sachan, Manish Jain, Manoj Varma, Rudra Pratap, Srinivasan Raghavan   +10 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Surface-defect engineering of metal nanoclusters for highly efficient electrocatalytic CO2 reduction

Nano Research
Defect engineering serves as a pivotal strategy for improving the performance of CO2 electrocatalytic reduction (CO2RR). However, understanding the structure-activity relationship between defect configurations and catalytic activity at the atomic level ...
Haoqi Li, Yafu Wang, Xiao Wei, Zhaohang Chen, Rui Ren, Xi Kang, Jiangwei Zhang, Manzhou Zhu   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Strain-modulated defect engineering of two-dimensional materials

npj 2D Materials and Applications
Strain- and defect-engineering are two powerful approaches to tailor the opto-electronic properties of two-dimensional (2D) materials, but the relationship between applied mechanical strain and behavior of defects in these systems remains elusive.
Prosun Santra, Sadegh Ghaderzadeh, Mahdi Ghorbani-Asl, Hannu-Pekka Komsa, Elena Besley, Arkady V. Krasheninnikov   +5 more
doaj   +1 more source