Results 61 to 70 of about 142,095 (261)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Olanzapine affects bone formation via oral Enterococcus through SAA1 gene and extracellular matrix-related pathways

Frontiers in Cellular and Infection Microbiology
BackgroundOlanzapine is a commonly used drug in the treatment of schizophrenia, but the mechanism of abnormal bone metabolism caused by olanzapine is still unclear.
Hui Yuan, Min-Yuan Wang, Min-Yuan Wang, Rui-Xi Liu, Senjeet Sreekissoon, Qiong Liu, Li Tan, Ya-Qiong Zhao, Meng-Mei Zhong, Qian Zhang, Xiao-Lin Su, Ning-Xin Chen, Mei Wang, Yi-Fan Yang, Jian-Nan Li, He-Qiong Zheng, Jin-Dong Chen, Yun-Zhi Feng, Feng-Yi Zhang, Yue Guo   +19 more
doaj   +1 more source

Defect engineered bioactive transition metals dichalcogenides quantum dots

Nature Communications, 2019
Transition metal dichalcogenide (TMD) quantum dots (QDs) have promising electronic properties which might be further tailorable by defect engineering. Here the authors describe a room temperature aqueous based synthesis of TMD QDs with controlled defect ...
Xianguang Ding, Fei Peng, Jun Zhou, Wenbin Gong, Garaj Slaven, Kian Ping Loh, Chwee Teck Lim, David Tai Leong   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Ultrahigh energy-storage dielectric ceramics via synergistic polymorphic nanodomain and defect design

Nature Communications
Dielectric capacitors are critical for advanced energy storage due to their ultrahigh power density and rapid charge-discharge rates. However, their application is limited by the low energy density.
Min Zhang, Yuzhou He, Hao Pan, Qinghua Zhang, Peixuan Jing, Weijia Guo, Hongdong Cai, Ce-Wen Nan, Yuan-Hua Lin   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

First-Principle Study of Optical Properties in Erbium-Doped Fibres for Enhanced Optical Signal Amplification [PDF]

Physics Access
The optical properties of silica, essential for applications ranging from fibre optics to UV transmission windows, are closely linked to atomic-scale defects, even though they are challenging to identify.
Umaru B Machu, Haruna Ali, Mohammed Y Onimisi, Joshua A Owolabi, Christiana O Akusu, Hassan G Muhammad, Ugbe R Ushiekpan, Abubakar Dalhat, Stephen C Nnochin, Alhassan Shuaibu, Isaac H Daniel   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Research on the application of defect engineering in the field of environmental catalysis

Green Energy & Environment
Researchers have recently developed various surface engineering approaches to modify environmental catalysts and improve their catalytic activity. Defect engineering has proved to be one of the most promising modification methods. Constructing defects on
Sirui Gao, Shunzheng Zhao, Xiaolong Tang, Long Sun, Qiyu Li, Honghong Yi   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source