Results 41 to 50 of about 3,022,656 (326)

When defects are not defects

open access: yesNature Materials, 2018
Line defects in two-dimensional borophene can self-assemble into new crystalline phases, blurring the distinctions between perfect and defective crystal.
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The relevance of point defects in studying silica-based materials from bulk to nanosystems [PDF]

open access: yes, 2019
The macroscopic properties of silica can be modified by the presence of local microscopic modifications at the scale of the basic molecular units (point defects).
Agnello S.   +4 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Next‐generation sequencing identifies rare pathogenic and novel candidate variants in a cohort of Chinese patients with syndromic or nonsyndromic hearing loss

open access: yesMolecular Genetics & Genomic Medicine, 2020
Background Hearing loss (HL) is a common sensory disorder in humans characterized by extreme clinical and genetic heterogeneity. In recent years, next‐generation sequencing (NGS) technologies have proven to be highly effective and powerful tools for ...
Yan‐Bao Xiang   +7 more
doaj   +1 more source

Cosmic defects and cosmology [PDF]

open access: yes, 2000
We provide a pedagogical overview of defect models of structure formation. We first introduce the concept of topological defect, and describe how to classify them.
Brandenberger, Robert, Magueijo, Joao
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Prognostic Nutritional Index Enhances the Discriminatory Ability of Procalcitonin for Predicting Pediatric Sepsis

open access: yesGlobal Pediatric Health
Objective. Improving diagnostic ability of pediatric sepsis is of great significance for reducing the mortality of sepsis. This study explored the discriminatory capacity of nutritional index (PNI) in pediatric sepsis. Methods.
Deng Hongya MBBS   +6 more
doaj   +1 more source

Describing codimension two defects [PDF]

open access: yes, 2014
Codimension two defects of the $(0,2)$ six dimensional theory $\mathscr{X}[\mathfrak{j}]$ have played an important role in the understanding of dualities for certain $\mathcal{N}=2$ SCFTs in four dimensions.
Balasubramanian, Aswin
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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