Results 31 to 40 of about 167,769,303 (287)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Health Research Consent Declaration Committee (HRCDC) annual activities report 2021

, 2022
During 2021 the COVID-19 pandemic continued to dominate and affect every facet of society including the Committee’s work. The critical importance of health research and the collaborative efforts of the research community, in Ireland and on a global ...
Health Research Consent Declaration Committee (HRCDC)
core  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Prescribing placebos ethically: the appeal of negatively informed consent [PDF]

, 2009
Kihlbom has recently argued that a system of seeking negatively informed consent might be preferable in some cases to the ubiquitous informed consent model. Although this theory is perhaps not powerful enough to supplant informed consent in most settings,
Shaw, D.M.
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

الرضا في عقد العمل الإلكتروني: دراسة مقارنة [PDF]

Al-Maǧallah Al-Qānūniyyaẗ
يتناول هذا البحث دراسة الرضا في عقد العمل الإلكتروني باعتباره أحد العقود الرضائية التي تنشأ بتلاقي إرادة طرفيها. يركز البحث على شروط التراضي في النظم القانونية التقليدية والحديثة، مع إبراز خصوصيات عقد العمل الإلكتروني فيما يتعلق بالإيجاب والقبول ، وطرق ...
تركى حامد الحازمي
doaj   +1 more source

Prevalence and risk factors of molar incisor hypomineralization in school children: A cross-sectional study in North Kerala, India

Journal of Orofacial Sciences, 2023
Introduction: Molar incisor hypomineralization (MIH) is a developmental enamel defect affecting permanent molars and incisors, leading to dental challenges. The prevalence and associated risk factors of MIH vary globally, highlighting the need for region-
Krishna Kumar Ramakrishnan, Joby Peter, Hridya Menon   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Characteristics Influencing Informed Consent on a Congenital Malformations Registry

, 1988
Maryland law requires that all babies born with "sentinel birth defects" be reported to the State Department of Health, but mothers may deny consent for further contact.
Robertson, Marion O., Law, Catherine, Wulff, Louise M., Panny, Susan R., and Wulff, Louise M.   +4 more
core   +1 more source

How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania. [PDF]

, 2010
BACKGROUND: HIV prevention trials conducted among disadvantaged vulnerable at-risk populations in developing countries present unique ethical dilemmas. A key concern in bioethics is the validity of informed consent for trial participation obtained from ...
Soteli, Selephina, Kavit, N, Stella Kasindi, Pool, Robert, Hayes, Richard J., Selephina Soteli, Shagi, Charles, Lees, S., Pool, R, Shagi, C, Lisa Vallely, Sheena McCormack, Kasindi, S., Hayes, Richard J, Soteli, S, Lees, Shelley, McCormack, S., Soteli, S., Vallely, L ; https://orcid.org/, Kavit, N., The Microbicides Development Programme, Vallely, Andrew, Hayes, R.J., Charles Shagi, Kavit, Natujwa, Shagi, C., Lees, SS, McCormack, Sheena, Shelley Lees, Vallely, A., Pool, R., Microbicides Development Programme (MDP), Richard J Hayes, ?, ?, null null, Vallely, A ; https://orcid.org/, Kasindi, S, Kasindi, Stella, Vallely, L., Mccormack, S, Vallely, Lisa, Andrew Vallely, Natujwa Kavit, Robert Pool, Hayes, R, Soteli Selephina, Lees Shelley, Kasindi Stella, McCormack Sheena, Kavit Natujwa, Vallely Andrew, Hayes Richard J, Shagi Charles, Vallely Lisa, Pool Robert   +54 more
core   +3 more sources