Results 81 to 90 of about 810,462 (294)
, 2016 Este proyecto consiste en el desarrollo de un videojuego 3D para poder experimentar los diferentes procesos a seguir durante el desarrollo como pueden ser el diseño, la programación, la creación de modelos, etc... Por lo tanto se ha hecho uso de la menor
Molero Hoyos, Francisco +1 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Town and country: Prague stands alone against Czech Republic’s nationalist president [PDF]
, 2016 The passionate demonstrations by the affluent Prague middle classes against the controversial behaviour of the Czech President Miloš Zeman will only deepen the rift between Prague and the rest of the Czech Republic, between the affluent and the ...
Culik, Jan
core
Escape Regions of the Active Target Defense Differential Game
, 2015 The active target defense differential game is addressed in this paper. In this differential game an Attacker missile pursues a Target aircraft. The aircraft is however aided by a Defender missile launched by, say, the wingman, to intercept the Attacker ...
Casbeer, David W. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
OBJECT-ORIENTED APPROACH TO IDENTIFYING THE RELEVANCE OF IT-EDUCATION TO THE LABOR MARKET DEMAND
Образование и наука, 2015 The paper deals with the issues of human resources development and IT-staff training. The authors put a special emphasis on bringing the IT-staff training system in line with the labor market demands both in quantitative and qualitative terms.
Masuma H. Mamedova, Faik R. Mamedzade
doaj +1 more source
Designing the Game to Play: Optimizing Payoff Structure in Security Games
, 2018 Effective game-theoretic modeling of defender-attacker behavior is becoming increasingly important. In many domains, the defender functions not only as a player but also the designer of the game's payoff structure.
Fang, Fei +4 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source