Results 71 to 80 of about 74,298 (249)

Annual report (Law Offices of the Mohave County Public Defender (Ariz.))

open access: yes, 2001
Report was compiled using actual caseloads in each of the three alternative providers adjusted for a common weighting factor. This weighting factor is the same weighting factor utilized in establishing staffing requirements and is predicated on American ...

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Adversarial Risk Análysis for Counterterrorism Modelling [PDF]

open access: yes, 2013
Recent large scale terrorist attacks have raised interest in models for resource allocation against terrorist threats. The unifying theme in this area is the need to develop methods for the analysis of allocation decisions when risks stem from the ...
Ríos, Jesús, Ríos Insúa, David
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The image of the warrior woman as a symbol of justice and independence in Uzbek literature

open access: yesНеофилология
INTRODUCTION. The image of the warrior woman in Uzbek culture and literature is examined as a symbol of justice, courage, independence, and strength of spirit, along with its role in reflecting ancient Turkic traditions of Central Asia.
S. A. Isniyazova, M. Kh. Egamova
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Chicago, Illinois 1959

open access: yes, 1959
"February, 1959."; "This map made available as a service of the Chicago Daily Defender."Grayscale1:84 ...
Chicago Urban League. Research Department;
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Tri-State Defender Front Page with Assassination Attempt Story and Picture

open access: yes, 1963
Microfilm scan of the front page of the Tri-State Defender containing a story about an assassination attempt on Hooks and other local civil rights leaders (A.W. Willis, Russell Sugarmon, and James Lawson).

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