Results 51 to 60 of about 51,208 (311)
Psicologia: Reflexão e Crítica, 2023 This study examines the influence of social support on bystander behaviors, the mediating and moderating effects of moral disengagement and defender self-efficacy at the individual and class levels, and their cross-level interaction.
Yuping Wu, Yanfang Zhou, Leishan Shi
doaj +1 more source
Synthese, 2016 Historical accounts of biological are thought to have, as a point in their favour, their being able to accommodate malfunction. Recently, this has been brought into doubt by Paul Sheldon Davies's argument for the claim that both selected malfunction (that of the selected functions account) and weak etiological malfunction (that of the weak etiological ...
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
To the Question of the Legal Position of Lawyer and Tactics of Protection by the Lawyer
Èkonomika, Pedagogika i Pravo, 2014 In the present article author carries out the analysis of position of the lawyer in connection with protection tactics formation. Author analyzes opinions of scientists-jurists. It is emphasized that developing a legal position, the defender has no right
Igor M. Potashnik
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
THE ROLE OF FORENSIC SPECIALISTS AS EXPERTS FOR THE DEFENSE
Теория и практика судебной экспертизы, 2015 The paper analyzes perspectives from the professional communities of legalscientists and lawyers on the issues of authority and significance of forensicexperts and their special knowledge when they represent the side of the defense.The author offers his ...
S. Zhdanov
doaj
Environmental and human rights defenders are vital in addressing ecosystem degradation and climate change. Operating on the frontlines in areas under pressure from legal and illegal forces, they mobilize communities to resist environmental harm and social injustices.
Risso, Melina +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source