Results 191 to 200 of about 92,909 (228)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

DC-FusionGNN: A Dual-Channel Framework Integrating Global Self-Attention and Local Topology Learning for Identifying Key Resistance Genes Against <i>Fusarium graminearum</i> Infection in Maize. [PDF]

Plants (Basel)
Dai Y, Qiao M, Fan J, Lu S, Zhao E, Zhu Y, Liu H, Zhang H.   +7 more
europepmc   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress. [PDF]

Adv Genet (Hoboken)
Zhu F, Huang K.
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Multi-omics reveals metabolic reprogramming underlying differential modulation of nodulation and root development by nitrate and ammonium in soybean. [PDF]

Front Plant Sci
Xu R, Kong X, Hu B, Chen M, Wang C, Qiu L, Yan Z.   +6 more
europepmc   +1 more source

Hypergolic Copper Cluster‐Based Covalent Organic Frameworks

Advanced Science, EarlyView.
Hpergolic cluster‐based covalent organic framework (Cu3‐CB‐COF), assembled from aldehyde‐functionalized carborane monomers and trinuclear copper clusters, demonstrates a strong synergy between its catalytic copper nodes and energetic carborane backbones.
Yu‐Zhou Qiao, Cai Li, Wen‐Yang Jiao, Guoqiang Sun, Xiao‐Fei Liu, Shuang‐Quan Zang   +5 more
wiley   +1 more source

Composite fiber Bragg grating written by femtosecond laser for Raman suppression in high-power fiber oscillators. [PDF]

Front Optoelectron
Li H, Zhao R, Rao B, Ye X, Yang B, Wang M, Li Z, Chen Z, Wang Z, Chen J.   +9 more
europepmc   +1 more source

Multi-Omics Analysis Identifies SlLhcb13 as a Key Regulator of Tomato Resistance to <i>Botrytis cinerea</i>. [PDF]

Plants (Basel)
Luo D, Peng X, Yan W, Wang Y, Liu K, Li L, Wu Z, Nie H, Sun S, Sun W, Cai J.   +10 more
europepmc   +1 more source