Results 41 to 50 of about 6,020 (300)

Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis

Frontiers in Immunology, 2022
Background/PurposeIn rheumatoid arthritis (RA) autoantibodies including antibodies to citrullinated protein antigens (ACPA) and rheumatoid factor (RF) can be predictive of incident clinical RA.
Dylan T. Bergstedt, Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane   +15 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Plea-Bargaining in German Criminal Procedure Law

İstanbul Hukuk Mecmuası, 2023
Plea-bargaining has been the most controversial issue for German criminal jurisprudence for the last thirty years. The German version of plea-bargaining first emerged as a clandestine mode of adjudication between the judge, defense counsel, and ...
Ali Emrah Bozbayındır
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Müdafilik Görevinin Yerine Getirilmesi Açısından Sır Saklama Yükümlülüğü

Ceza Hukuku ve Kriminoloji Dergisi
Ceza muhakemesi sürecinde yargılama makamının maddi gerçeğe en doğru şekilde ulaşabilmesi için savunma makamının, savunmayı gereği gibi yerine getirebilme imkânına sahip olması gerekir. Dolayısıyla şüpheli veya sanığın, sırrının açık edileceğinden endişe
Özge Ceren Yavuz Kılıç
doaj   +1 more source

Disclosure of evidence in pre-trial proceedings and investigation [PDF]

Strani pravni život, 2020
Disclosure of evidence to the defendant and defense counsel during pre-trial proceedings and investigations is important for the defendant to be able to devise a defense strategy and to suggest the taking of other evidentiary actions during the ...
Živković Natalija M.
doaj  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

A Defense of the Command/Counsel Distinction Based on Matthew 19 and 1 Corinthians 7

Journal of Moral Theology, 2021
As a two-tiered ethic is typically articulated, all Christians are required to live the commandments, but only some live the counsels. As a result, a kind of minimalistic ethic grows up around the laity, whereas religious are called to a higher holiness.
John Meinert
doaj  

Appointment of ex officio defence counsel in cases of mandatory defence: Dilemmas in case law with reference to the CPC of the so-called Kosovo [PDF]

Baština
The provisions on the appointment of an ex officio defence counsel in cases of compulsory defence are not essential for criminal proceedings. However, if the provisions on the engagement of a defense attorney in situations where his presence is necessary
Milović Marko M.
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source