Results 81 to 90 of about 1,092,582 (286)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Ego defense mechanism reflected in nicholas sparks' the last song (2009) : a psychoanalytic perspective [PDF]

open access: yes, 2014
This study is about ego defense mechanism of major character in The Last Song novel. The problem of the study is ego defense mechanism reflected in Nicholas Sparks’ The Last Song viewed from psychoanalytic perspective.
, Dr. M. Thoyibi, M.S   +2 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Mekanisme Pertahanan Konflik Dalam Novel Tak Sempurna Karya Fahd Djibran: Tinjauan Psikologi Sastra Dan Implementasinya Sebagai Bahan Ajar Sastra Di Smp Muhammadiyah Darul Arqom Karanganyar [PDF]

open access: yes, 2015
DEFENSE MECHANISM OF CONFLICT IN THE TAK SEMPURNA NOVEL BY FAHD DJIBRAN: LITERATURE PSYCHOLOGICAL REVIEW AND IMPLEMENTATION AS LITERARY LEARNING MATERIAL IN SMP MUHAMMADIYAH DARUL ARQOM, KARANGANYAR Nur Wijayanto, A 310 100 034.
, Dra. Main Sufanti, M. Hum.   +1 more
core  

Lockdown: Dynamic Control-Flow Integrity

open access: yes, 2014
Applications written in low-level languages without type or memory safety are especially prone to memory corruption. Attackers gain code execution capabilities through such applications despite all currently deployed defenses by exploiting memory ...
Barresi, Antonio   +2 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Alexithymia and defense mechanisms in patients with depression, generalized anxiety disorder, obsessive-compulsive disorders and normal individuals: A comparative study

open access: yesمجله علوم روانشناختی, 2018
Individuals with emotional problems experience uncontrollable and intensive negative affect. They do not have the ability to manage and regulate their acute emotional experiences.
MohammadAli Besharat   +3 more
doaj  

Holly Kennedy’s defense mechanism in PS. I Love You by Cecelia Ahern [PDF]

open access: yes, 2017
This thesis analyzes a novel written by Cecelia Ahern entitled PS. I Love You. This novel tells about Holly Kennedy’s struggle against her sadness after her husband’s death.
Sabatini, Elia Elsa
core  

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