Results 61 to 70 of about 1,106,202 (340)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Wisdom of Honeybee Defenses Against Environmental Stresses

Frontiers in Microbiology, 2018
As one of the predominant pollinator, honeybees provide important ecosystem service to crops and wild plants, and generate great economic benefit for humans.
Guilin Li, Hang Zhao, Zhenguo Liu, Hongfang Wang, Baohua Xu, Xingqi Guo   +5 more
doaj   +1 more source

Comparative analysis of Salmonella susceptibility and tolerance to the biocide chlorhexidine identifies a complex cellular defense network [PDF]

, 2014
peer-reviewedChlorhexidine is one of the most widely used biocides in health and agricultural settings as well as in the modern food industry. It is a cationic biocide of the biguanide class. Details of its mechanism of action are largely unknown.
Aine eSheridan, Catherine Maeve Burgess, Jarlath eNally, Jay C. D. Hinton, Jay C. D. Hinton, Jenny eRenaut, Karen ePower, Kjell eSergeant, Kristian eHandler, Orla eCondell, Orla eCondell, Sarah eFinn, Seamus eFanning, Seamus eFanning   +13 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modeling Active Group Defense Mechanisms In Prey-Predator Interactions

Journal of Applied Science and Engineering
This article focuses on the study of active group defense in prey, where they defend themselves against attacking predators as a group. The aim of this paper is to create a mathematical model to examine the functional response resulting from active group
R. GEETHA, K. SATHIYANATHAN
doaj   +1 more source

Defense Mechanisms in E. a. Poe's Selected Short Stories the Black Cat & the Tell-Tale Heart [PDF]

, 2018
Defense mechanism is strategies the ego uses to defend itself against the anxiety provoked by conflicts. The aim of the research is to describe the types of defense mechanism in two of Poe's selected short stories, The Black Cat & The Tell-Tale Heart ...
Tenrisanna, R. (Rasynal)
core  

Defensive Dropout for Hardening Deep Neural Networks under Adversarial Attacks

, 2018
Deep neural networks (DNNs) are known vulnerable to adversarial attacks. That is, adversarial examples, obtained by adding delicately crafted distortions onto original legal inputs, can mislead a DNN to classify them as any target labels.
Chin, Peter, Kaeli, David, Lin, Xue, Wang, Siyue, Wang, Xiao, Wen, Wujie, Zhao, Pu   +6 more
core   +1 more source

CADENCE’S DEFENSE MECHANISM IN RECOVERING HER LOST MEMORY IN WE WERE LIARS BY E. LOCKHART [PDF]

, 2018
LA PREECLAMPSIA DIFERENCIAS EPIDEMIOLÓGICAS ENTRE PREECLAMPSIA DE INICIO TEMPRANO (PRECOZ) CON PREECLAMPSIA DE INICIO TARDÍO DIFERENCIAS CLÍNICAS ENTRE PIP Y PIT INVASIÓN TROFOBLÁSTICA DEFICIENTE, LA HIPOPERFUSIÓN PLACENTARIA ANÁLISIS DE ANTECEDENTES ...
Soegijono, MegalisthaPratiwi
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the Importance of Host MicroRNAs During Viral Infection

Frontiers in Genetics, 2018
Every living organism has to constantly face threats from the environment and deal with a large number of pathogens against which it has to defend itself to survive.
Erika Girardi, Paula López, Sébastien Pfeffer   +2 more
doaj   +1 more source