Results 51 to 60 of about 1,106,202 (340)

Change in coping and defense mechanisms across adulthood: Longitudinal findings in a European American sample. [PDF]

, 2014
This study examined longitudinal changes in coping and defense mechanisms in an age- and gender-stratified sample of 392 European-American adults. Nonlinear age-related changes were found for the coping mechanisms of sublimation and suppression and the ...
Chui, Helena, Diehl, M., Grühn, D., Hay, E.L., Labouvie-Vief, G., Lumley, M.A.   +5 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1

Frontiers in Immunology
BackgroundIncreased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have been found to correlate with poor clinical outcomes in patients with cancer. Although abundant data support the involvement of PAI-1 in cancer progression, whether PAI-
Abd Aziz Ibrahim, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata   +9 more
doaj   +1 more source

Deciphering the Genome-Wide Transcriptomic Changes during Interactions of Resistant and Susceptible Genotypes of American Elm with Ophiostoma novo-ulmi

Journal of Fungi, 2022
Dutch elm disease (DED), caused by Ophiostoma novo-ulmi (Onu), is a destructive disease of American elm (Ulmus americana L.). The molecular mechanisms of resistance and susceptibility against DED in American elm are still largely uncharacterized.
Md Tabibul Islam, Jose Freixas Coutin, Mukund Shukla, Amandeep Kaur Dhaliwal, Martha Nigg, Louis Bernier, Sherif M. Sherif, Praveen K. Saxena   +7 more
doaj   +1 more source

QuSecNets: Quantization-based Defense Mechanism for Securing Deep Neural Network against Adversarial Attacks

, 2019
Adversarial examples have emerged as a significant threat to machine learning algorithms, especially to the convolutional neural networks (CNNs).
Ahmed, Rehan, Ali, Hassan, Hanif, Muhammad Abdullah, Khalid, Faiq, Rehman, Semeen, Shafique, Muhammad, Tariq, Hammad   +6 more
core   +1 more source

Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model. [PDF]

, 2014
Pulmonary tuberculosis (TB), caused by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb), is a major world health problem. The production of reactive nitrogen species (RNS) is a potent cytostatic and cytotoxic defense mechanism ...
A Burgess, A Koul, A Kumar, A Trivedi, A Vazquez-Torres, AK Azad, AM Cooper, AM van der Sar, Annemarie H. Meijer, C Aston, C Bogdan, C Hall, C Jagannath, C Moreno, C Nathan, C Nathan, C Peyssonnaux, CA Loynes, CJ Cambier, CJ Hall, CS Yang, CT Yang, D Chakravortty, D Le Guyader, DE Goldberg, DM Tobin, E Pagan-Ramos, E Peranzoni, EA Rich, ED Chan, EJ Stoop, Emi Murayama, Esther Schutz, FJ Roca, G Wu, GS Jones, H Clay, H Clay, HD Brightbill, HE Volkman, HE Volkman, Herman P. Spaink, I Vergne, J Chan, J Chan, J Idh, J Lee, JB Sampson, JD Lambeth, JD MacMicking, JL Flynn, JM Davis, JT Mattila, KA Rockett, KM Guinn, L Ramakrishnan, L Ramakrishnan, LB Adams, LE Swaim, LE Via, LY Gao, M Baggiolini, M Buxade, M Chawla, M Forlenza, M Gengenbacher, M Parikka, M van der Vaart, M van der Vaart, MA De Groote, MI Voskuil, Michael J. Redd, Michiel van der Vaart, Nicholas S. Foulkes, NJ Gay, Philip M. Elks, PJ Cardona, PM Elks, PM Elks, Q Deng, R Bryk, R Long, R Pacelli, S de Oliveira, S Ehrt, S Lepiller, S Lepiller, S Nicholson, S Pfeiffer, SA Renshaw, SR Krutzik, SR Walmsley, T Cramer, T Masaki, T Ulrichs, Vincent van Hensbergen, WL Lee, Y Zhang, YL Lau, Z Toossi   +99 more
core   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles
Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
doaj   +1 more source

Variation of the Antioxidative Defense in Elaeis guineensis Jacq. Facing Bud Rot Disease in the Coastal Area of Ecuador

Molecules, 2022
Elaeis guineensis Jacq. has gained a reputation in the food industry as an incredible crop capable of supplying the world’s largest edible oil production.
Raluca A. Mihai, Galo M. Canchignia Guacollantes, Sebastián A. Villacrés Mesias, Larisa I. Florescu, Rodica D. Catana   +4 more
doaj   +1 more source