Results 41 to 50 of about 1,106,202 (340)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Magnitude and Factors Associated with Research Misconduct at a Public University in Ethiopia: A Cross-Sectional Survey [version 2; peer review: 2 approved]

F1000Research
Background Research integrity, essential for ethical scientific research, has been inadequately addressed in Ethiopia, resulting in gaps in addressing misconduct like plagiarism, falsification and fabrication.
Habtamu Belay Hailu, Sintayehu Tsegaye Bitew, Joseph Ali, Betselot Yirsaw Wubete, Telahun Teka Wolde   +4 more
doaj   +1 more source

Plant Flavonoids in Mediterranean Species: A Focus on Flavonols as Protective Metabolites under Climate Stress

Plants, 2022
Flavonoids are specialized metabolites largely widespread in plants where they play numerous roles including defense and signaling under stress conditions.
Justine Laoué, Catherine Fernandez, Elena Ormeño   +2 more
doaj   +1 more source

Defense Mechanism Of Amba Reflected In Laksmi Pamuntjak’s The Questions Of Red Novels (2014): A Psychoanalytic Approach [PDF]

, 2017
This research aims to analyze defense mechanism of Amba, reflected on Laksmi Pamuntjak’s The Questions of Red novel, the purpose of the research is reveal what is defense mechanism, what kind of defense mechanism and how is defense mechanism reflected in
, Dr. Abdillah Nugroho, M.Hum, Kahar, Fitrah Abdul   +1 more
core  

MTDeep: Boosting the Security of Deep Neural Nets Against Adversarial Attacks with Moving Target Defense

, 2019
Present attack methods can make state-of-the-art classification systems based on deep neural networks misclassify every adversarially modified test example.
A Escalera De La, B Biggio, O Russakovsky, R Jayadevan   +3 more
core   +1 more source

Protozoan-induced regulation of cyclic lipopeptide biosynthesis Is an effective predation defense mechanism for Pseudomonas fluorescens [PDF]

, 2009
Environmental bacteria are exposed to a myriad of biotic interactions that influence their function and survival. The grazing activity of protozoan predators significantly impacts the dynamics, diversification, and evolution of bacterial communities in ...
Bruijn, I., de, Cohen, M.F., Mazzola, M., Raaijmakers, J.M.   +3 more
core   +3 more sources

The pathogen Moniliophthora perniciosa promotes differential proteomic modulation of cacao genotypes with contrasting resistance to witches´ broom disease [PDF]

, 2020
Background: Witches' broom disease (WBD) of cacao (Theobroma cacao L.), caused by Moniliophthora perniciosa, is the most important limiting factor for the cacao production in Brazil.
Correa, Stephany Cristiane, Cruz dos Santos, Everton, Gramacho, Karina Peres, Micheli, Fabienne, Pirovani, Carlos Priminho   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition

Cell Death Discovery
Plasminogen activator inhibitor-1 (PAI-1) is significantly upregulated during inflammatory responses, and elevated PAI-1 levels are associated with poor prognosis in various diseases.
Abd Aziz Ibrahim, Hiromi Miura, Tomoya Terada, Masaki Kawarada, Nobuo Watanabe, Hiroyuki Hosokawa, Masato Ohtsuka, Toshio Miyata, Takashi Yahata   +8 more
doaj   +1 more source

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis

iScience
Summary: AMBRA1, which was initially reported to be essential for nervous system development via autophagy and cell proliferation control, also functions as a tumor suppressor by regulating the ubiquitination of D-type cyclins through interaction with ...
Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki, Norio Yamamoto, Katsuto Hozumi, Tomoaki Tanaka, Hirofumi Nakaoka, Kazuyoshi Hosomichi, Yu Hamaguchi, Michiaki Hamada, Yoshiki Shiraishi, Akihide Kamiya, Yoshihiko Nakamura, Kaito Harada, Abd Aziz Ibrahim, Takashi Yahata, Masato Ohtsuka, Naoya Nakamura, Hiroyuki Hosokawa, Minoru Kimura, Ituro Inoue, Takehito Sato   +28 more
doaj   +1 more source