Results 81 to 90 of about 9,269,203 (381)

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]

open access: yes, 2012
Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Albuquerque, Boris   +5 more
core   +1 more source

Software-defined Networking-based DDoS Defense Mechanisms

open access: yesACM Computing Surveys, 2019
Distributed Denial of Service attack (DDoS) is recognized to be one of the most catastrophic attacks against various digital communication entities.
Rochak Swami, M. Dave, V. Ranga
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Psychological defense and academic achievement within pupils

open access: yesRUDN Journal of Ecology and Life Safety, 2013
The present article is devoted to the issue of correlation between scholars’ academic achievement and defense mechanisms. A proprietary diagnostic technique of defense mechanisms is described.
V A Negrii
doaj  

Теоретичний аналіз проблеми дослідження механізмів психологічного захисту підлітків [PDF]

open access: yes, 2010
В статті розглядаються теоретико-методологічні засади вивчення механізмів психологічного захисту підлітків. Аналізуються як зарубіжні так і вітчизняні підходи до розуміння природи механізмів психологічного захисту.The article discusses theoretical and ...
Кирпенко, Т.М.
core  

Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]

open access: yes, 2008
The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T.   +6 more
core   +2 more sources

Interactions between nanoparticles and plants: phytotoxicity and defense mechanisms

open access: yes, 2017
With the rapid development of nanotechnology, the potential releases of nanoparticles (NPs) have drawn considerable attention. Plants are essential fundamental components of all ecosystems, and the interaction between NPs and plants is an indispensable ...
Jie Yang, W. Cao, Y. Rui
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The dendritic cell niche in chronic obstructive pulmonary disease. [PDF]

open access: yes, 2012
The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD).
Haczku, Angela
core   +3 more sources

Phage defense mechanisms and their genomic and phenotypic implications in the fish pathogen Vibrio anguillarum

open access: yesFEMS Microbiology Ecology, 2019
&NA; Vibrio anguillarum is a marine bacterium that can cause vibriosis in many fish and shellfish species. Although phage therapy has been proposed as an alternative treatment, the defense mechanisms against phage infection in V.
D. Castillo   +7 more
semanticscholar   +1 more source

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