Results 21 to 30 of about 85,538 (123)

A case of papillary renal cell carcinoma with para‐aortic lymph node metastasis that was completely resectable after treatment with combination therapy comprising lenvatinib and pembrolizumab and robot‐assisted radical nephrectomy

IJU Case Reports
Introduction Combination therapy comprising immune checkpoint inhibitors and molecular targeted therapies can be effective for metastatic non‐clear cell renal cell carcinoma.
Takayuki Hosoi, Shunsuke Yoshioka, Akari Hiraguri, Yusuke Kirihana, Tomoyuki Koguchi, Makoto Tamaki, Chiharu Irisawa   +6 more
doaj   +2 more sources

Assessing the survival advantage of deferred cytoreductive nephrectomy using a prediction interval. [PDF]

Int J Surg, 2023
Hung KC, Tsai IT, Sun CK.
europepmc   +3 more sources

Editorial Comment to Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab. [PDF]

IJU Case Rep, 2021
Yuasa T.
europepmc   +4 more sources

Comparison of upfront versus deferred cytoreductive nephrectomy in patients with metastatic renal cell carcinoma receiving systemic therapy: a systematic review and meta-analysis. [PDF]

Int J Surg, 2023
Background: This study aimed to conduct a pooled analysis to compare the outcomes of patients with metastatic renal cell carcinoma who received presurgical systemic therapy [(ST); including immunotherapy and/or targeted therapy] followed by cytoreductive nephrectomy (CN) [(deferred CN; (dCN)] with those who ...
Li KP, He M, Wan S, Chen SY, Wang CY, Li XR, Yang L.   +6 more
europepmc   +3 more sources

Variations in the exposure to sunitinib with immediate and deferred cytoreductive nephrectomy (CN). A post-hoc analysis of the randomized controlled EORTC SURTIME trial

European Urology Open Science, 2020
Y. Abu-Ghanem, H. Van Thienen, C. Blank, T. Powles, L. Collette, B. Tombal, J. Haanen, A. Bex   +7 more
doaj   +2 more sources

Achieving Complete Cytoreduction After Systemic Therapy for Stage IV Renal Carcinoma With Multicompartment Recurrence and Peritoneal Carcinomatosis: A Case Report. [PDF]

Case Rep Oncol Med
Clear cell renal cell carcinoma (ccRCC) most commonly metastasizes to the lungs, bones, liver, and brain, whereas peritoneal involvement is exceedingly rare and typically associated with aggressive disease and poor prognosis. Although the combination of immune checkpoint inhibitors and tyrosine kinase inhibitors has significantly improved outcomes in ...
Usubillaga JP, Varela R, Reina Y, Franco DC, Valderrama JS, Zapata-Laguado M, Suso-Palau D.   +6 more
europepmc   +2 more sources

Efficacy of immunotherapy-based immediate cytoreductive nephrectomy vs. deferred cytoreductive nephrectomy in metastatic renal cell carcinoma.

European review for medical and pharmacological sciences, 2023
This study was performed to evaluate the efficacy of immediate cytoreductive nephrectomy (CRN) followed by programmed cell death factor-1 (PD-1) inhibitors vs. deferred CRN after the administration of 4 cycles of neoadjuvant therapy using nivolumab preceding the debulking and postoperative chemotherapy in metastatic renal cell carcinoma (mRCC).We ...
Shen, X.-P., Xie, M., Wang, J.-S., Guo, X.   +3 more
openaire   +2 more sources

Cytoreductive nephrectomy in the era of immune-checkpoint inhibitors: back to the future? [PDF]

BJU Int
Objective To investigate the role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) treated with immune‐checkpoint inhibitors (ICIs). Methods A narrative review was carried out using PubMed and searching for English articles published from January 2015 to May 2025.
Flammia RS, Campi R, Bologna E, Bertolo R, Leonardo C, Calabrò F, Amparore D, Simone G, Young Academic Urologists (YAU) Renal Cancer Working Group.   +8 more
europepmc   +2 more sources

Stereotactic body radiation therapy to the kidney for metastatic renal cell carcinoma: A narrative review of an emerging concept

Cancer Treatment and Research Communications, 2023
This narrative review provides a historical overview of cytoreductive nephrectomy for metastatic renal cell carcinoma (mRCC) and examines the safety and therapeutic potential of cytoreductive stereotactic body radiation therapy (SBRT) for mRCC in the ...
Claire Hao, Jason Liu, Colton Ladbury, Tanya Dorff, Sagus Sampath, Sumanta Pal, Savita Dandapani   +6 more
doaj   +1 more source

Spontaneous regression of metastatic renal cancer and improvement in IMDC risk criteria prior to cytoreductive nephrectomy

Urology Case Reports, 2023
A 57-year-old male presented with a 2-month history of a cough, weight loss, chest discomfort and night sweats. He was diagnosed with poor prognosis metastatic Renal Cancer (RCC) according to International Metastatic RCC Database Consortium (IMDC ...
Kay McGillivray, Roisin McKenna, Grenville Oades, Flora Rodger   +3 more
doaj   +1 more source