Results 51 to 60 of about 85,538 (123)

PrimerX: A Bayesian Multistage Cohort Embedded Randomised Trial to Evaluate the Role of Deferred Local Therapy of the Primary Tumour in Combination with Immune Checkpoint Inhibitor–based First-line Therapy in Metastatic Renal Cell Carcinoma Patients

European Urology Open Science
Background: Historically, patients with metastatic renal cell carcinoma (mRCC) have been offered upfront cytoreductive nephrectomy (CN) followed by systemic therapy.
Orlane Figaroa, Patricia Zondervan, Rob Kessels, Johannes Berkhof, Maureen Aarts, Paul Hamberg, Maartje Los, Djura Piersma, Bart Rikhof, Britt Suelmann, Metin Tascilar, Astrid van der Veldt, Paul Verhagen, Hans Westgeest, Hilin Yildirim, Axel Bex, Adriaan Bins   +16 more
doaj   +1 more source

Synchronous Bilateral Large Renal Cell Carcinoma Treated With Presurgical Pembrolizumab and Lenvatinib Enabling Unilateral Partial Nephrectomy and Dialysis Avoidance: A Case Report

IJU Case Reports, Volume 8, Issue 6, Page 587-590, November 2025.
ABSTRACT Introduction Synchronous bilateral renal cell carcinoma is a rare clinical entity that poses considerable challenges in establishing an optimal treatment strategy. Case Presentation A 56‐year‐old woman had synchronous bilateral renal cell carcinoma, with tumors in the right (61 mm) and left (71 mm) kidneys.
Hiroki Kawabata, Shimpei Yamashita, Yuya Iwahashi, Satoshi Muraoka, Takahito Wakamiya, Yasuo Kohjimoto, Isao Hara   +6 more
wiley   +1 more source

Large‐cell neuroendocrine carcinoma of the kidney effectively treated by nivolumab and ipilimumab

IJU Case Reports, Volume 8, Issue 2, Page 89-92, March 2025.
Introduction Neuroendocrine tumors originating in the kidney are rare, and standard treatments are not established. Case presentation An 80‐years‐old man was referred to our hospital with renal dysfunction and a left renal mass. Based on CT and bone scintigraphy results, he was diagnosed as having a large left renal tumor with a thrombus in the ...
Nodoka Okubo, Takashi Kabuto, Hisato Kobayashi, Junya Kimura, Yoshiaki Imamura, Masaya Seki, So Inamura, Minekatsu Taga, Masato Fukushima, Naoki Terada   +9 more
wiley   +1 more source

Rapid symptomatic and radiological response to pembrolizumab–lenvatinib in a 30-year-old man with metastatic sarcomatoid renal cell carcinoma not otherwise specified and extensive osteolytic bone disease

Drugs in Context
Sarcomatoid dedifferentiation and bone metastases characterize an aggressive subset of metastatic renal cell carcinoma (mRCC) with a poor prognosis.
Giorgia Novero, Isabella Cavaglià, Luisa Delsedime, Ilaria Depetris, Roberto Filippi   +4 more
doaj   +1 more source

Efficacy of immune checkpoint inhibitor combination therapy prior to nephrectomy in advanced renal cell carcinoma: A retrospective pilot study

BJUI Compass, Volume 5, Issue 10, Page 1071-1074, October 2024.
Abstract Renal cell carcinoma (RCC) affects 10%–20% of patients annually, often with metastases present. This study evaluated the impact of systemic therapy before nephrectomy in patients with unresectable or metastatic renal cell carcinoma (RCC). Patients receiving upfront immune checkpoint inhibitor (ICI) combination therapy showed significantly ...
Sho Kiyota, Takashi Yoshida, Takahiro Nakamoto, Eri Jino, Takao Mishima, Hidefumi Kinoshita   +5 more
wiley   +1 more source

Surgical Safety of Deferred Cytoreductive Nephrectomy Following Pretreatment with Immune Checkpoint Inhibitor–based Dual Combination Therapy [PDF]

European Urology Oncology, 2022
Niels M, Graafland, Bernadett, Szabados, Chandran, Tanabalan, Teele, Kuusk, Faiz, Mumtaz, Ravi, Barod, David, Nicol, Ekaterini, Boleti, Tom, Powles, John B, Haanen, Axel, Bex   +10 more
openaire   +2 more sources

Renal cancer: signaling pathways and advances in targeted therapies

MedComm, Volume 5, Issue 8, August 2024.
Comprehensive summary of therapeutic strategies and corresponding targets in renal cancer. Abstract Renal cancer is a highlyheterogeneous malignancy characterized by rising global incidence and mortalityrates. The complex interplay and dysregulation of multiple signaling pathways,including von Hippel–Lindau (VHL)/hypoxia‐inducible factor (HIF ...
Aimin Jiang, Jinxin Li, Ziwei He, Ying Liu, Kun Qiao, Yu Fang, Le Qu, Peng Luo, Anqi Lin, Linhui Wang   +9 more
wiley   +1 more source

Report of case series: Correlation between pathological and radiological evaluation and clinical course of three cases of metastatic renal cell carcinoma with cytoreductive nephrectomy after combined immuno‐oncology therapy

IJU Case Reports, Volume 7, Issue 4, Page 341-345, July 2024.
Introduction The pathologic evaluation and clinical course of cytoreductive nephrectomy after combined immuno‐oncology therapy were reviewed to understand the benefits of cytoreductive nephrectomy. Case presentation Three patients with clear cell carcinoma underwent tumor biopsy before combined immuno‐oncology therapy.
Yuichiro Atagi, Kouki Tada, Reina Kouno, Ryoei Minato, Katsuyoshi Hashine   +4 more
wiley   +1 more source

The role of cytoreductive nephrectomy in metastatic renal cell carcinoma in immune-oncology era (SEVURO-CN): study protocol for a multi-center, prospective, randomized trial

Trials
Background The role of cytoreductive nephrectomy (CN) in the treatment of metastatic renal cell carcinoma (mRCC) remains unclear in the immuno-oncology (IO) era. The results of two randomized trials, CARMENA and SURTIME, questioned the role and timing of
Jee Soo Park, Jongchan Kim, Jinhyung Jeon, Jongsoo Lee, Won Sik Jang, Seung Hwan Lee, Woong Kyu Han, Young Deuk Choi, Kyo Chul Koo, Kang Su Cho, Byung Ha Chung, Won Sik Ham   +11 more
doaj   +1 more source

‘Case of the Month’ from Addenbrooke's Hospital, Cambridge, UK: surgery after near complete response to combined immunotherapy and tyrosine kinase inhibitor therapy for metastatic renal cell carcinoma with inferior vena cava tumour thrombus

BJU International, Volume 136, Issue 4, Page 613-616, October 2025.
James P. Blackmur, James N. Armitage, James O. Jones, Antony C.P. Riddick, Thomas J. Mitchell, William H.J. Ince, Sona Appukutty, Anne Y. Warren, Kate Fife, Brent O'Carrigan, Grant D. Stewart   +10 more
wiley   +1 more source