Results 101 to 110 of about 1,820,267 (314)

Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid [PDF]

, 2009
The risk of nutrient deficiencies increases with age in our modern Western society, and vitamin B(12) deficiency is especially prevalent in the elderly and causes increased homocysteine (Hcy) and methylmalonic acid (MMA) levels.
Bravenboer, N., Vaes, Bart L T, Vaes, B.L.T., Everts, V., Wilma T. Steegenga, Bravenboer, Nathalie, Steegenga, W.T., Lute, Carolien, Carolien Lute, de Groot, L.C.P.G.M., Müller, M.R., Henk J. Blom, Dhonukshe-Rutten, R.A.M., de Groot, Lisette C P G M, Dhonukshe-Rutten, R.A., Bart L. T. Vaes, Teun J. de Vries, Blom, Henk J, Nathalie Bravenboer, de Vries, Teun J, Müller, Michael, Everts, Vincent, Rosalie A. Dhonukshe-Rutten, Michael Müller, de Vries, T.J., Lisette C. P. G. M. de Groot, Dhonukshe-Rutten, Rosalie A, Steegenga, Wilma T, Groot, C.P.G.M., de, Lute, C., Blom, H.J., Vries, T.J., de, Vincent Everts, Müller, M.   +33 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Prevalence and risk factors for vitamin C deficiency in North and South India: A two centre population based study in people aged 60 years and over [PDF]

, 2011
BackgroundStudies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries.ObjectivesTo investigate the prevalence ...
K. Gupta Sanjeev, Maraini Giovanni, Ravilla D. Ravindran, Giovanni Maraini, Ravilla Thulasiraj D., John Neena, Thulasiraj D. Ravilla, John, Neena, Thulasiraj D Ravilla, Young, Ian S., R Jayanthi, S. Young Ian, Usha Chakravarthy, Chakravarthy Usha, Fletcher Astrid E., Young, Ian S, Ravilla D Ravindran, Praveen Vashist, Ravilla, Thulasiraj D, Chakravarthy, Usha, Kathryn E. Fitzpatrick, Fitzpatrick, Kathryn E, Camparini, Monica, Astrid E Fletcher, Gupta, S.K., R. Jayanthi, Maraini, G., John, N., Ravilla, T.D., Fitzpatrick Kathryn E., Fitzpatrick, K.E., Maraini, Giovanni, Camparini, M., Fletcher, Astrid E, Gupta, Sanjeev K, Monica Camparini, Kathryn E Fitzpatrick, Ravindran, Ravilla D, Neena John, Fletcher, A.E., Jayanthi, R, Sanjeev K Gupta, Ravindran, R.D., Vashist Praveen, Sanjeev K. Gupta, Vashist, Praveen, Astrid E. Fletcher, Camparini Monica, Ian S Young, Jayanthi R., Jayanthi, R., Ravindran Ravilla D., Vashist, P., Ian S. Young   +53 more
core   +2 more sources

Mechanisms of endothelial injury and transplant-associated thrombotic microangiopathy in tandem autologous hematopoietic stem cell transplant for neuroblastoma

Haematologica, 2023
Anthony Sabulski, Sheyar Abdullah, Nathan Luebbering, Benjamin Aunins, Caitlin Castillo, Kelly Lake, Alexandra Duell, Lauren Strecker, Lucille Langenberg, William Broomhead, Scott DiMeo, Elizabeth A. Odegard, Jason T. Blackard, Assem G. Ziady, Alix E. Seif, Christopher E. Dandoy, Benjamin L. Laskin, Sonata Jodele, Stella M. Davies   +18 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Human IFNAR2 deficiency : lessons for antiviral immunity [PDF]

, 2015
C.J.A.D. was supported by the Academy of Medical Sciences (AMS-SGCL11), the British Infection Association, and the UK NIH Research (NIHR); S.M.B.M. was supported by the Universiti Sains Malaysia Fellowship; K.R.E. and S.H. were supported by the Sir Jules
Cant, Andrew J., Skelton, Andrew J., Leahy, T. Ronan, Morfopoulou, Sofia, Mohamad, Siti M. B., Dempsey, Eugene, Lynch, Niamh E., McMahon, Cathy, Breuer, Judith, Hubank, Mike, Valappil, Manoj, Duncan, Christopher J. A., Connell, Jeff, Jacques, Thomas S., Engelhardt, Karin R., Hambleton, Sophie, Butler, Karina M., Randall, Richard Edward, Young, Dan Frushard, Munday, Diane Carolyn, Gavin, Patrick J., Brown, Julianne R., Randall, Richard Edward; id_orcid   +22 more
core   +1 more source

Immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies: impact of infusion method on immunoglobulin-specific perceptions of quality of life and treatment satisfaction

Allergy, Asthma & Clinical Immunology
Background Immunoglobulin replacement therapy (IgRT) is the current standard of care for primary antibody deficiency patients (majority of all primary immunodeficiency (PID) diseases), with growing real-world evidence supporting use for secondary ...
Rajiv Mallick, Noemi Hahn, Christopher Scalchunes   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source