Results 191 to 200 of about 1,306,265 (264)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Suspected acquired factor XIII deficiency in a man living with HIV: diagnostic and therapeutic challenges in recurrent spontaneous hemorrhage: a case report. [PDF]

Front Med (Lausanne)
He W, Chen J, Wu H.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Retiring rusty myths around intravenous iron. [PDF]

Hemasphere
Merz LE, Langer AL.
europepmc   +1 more source

Thyroid Function Parameters, Thyroid Status, and Vitamin B12 Deficiency in Hospitalized Adults: A Retrospective Cross-Sectional Study in Eastern India. [PDF]

Cureus
Priyadarshi K, Ansari Z, Pathak S, Mishra N, Khan MKJ, Kumari S, Shafi S, Khan IA, Singh P.   +8 more
europepmc   +1 more source

Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study. [PDF]

Eur J Pediatr
Oktay MA, Döğer E, Uğurlu AK, Kayhan G, Karaoğuz MY, Çamurdan MO, Bideci A.   +6 more
europepmc   +1 more source

Vitamin K status and vascular calcification biomarkers as determinants of carotid plaque in peritoneal dialysis: a prospective study. [PDF]

Ren Fail
Pamuk I, Cetin TE, Kindan BH, Akcay OF, Yildirim S, Sendur HN, Cerit MN, Gonen S, Akhan BM, Derici U, Guz G, Helvaci O.   +11 more
europepmc   +1 more source

The relationships between fat-soluble vitamin deficiency and childhood obesity risk. [PDF]

Front Pediatr
Zhou F, Li X, Zhu L, Jin Z, Fu H, Guo Z, Fang Y.   +6 more
europepmc   +1 more source