Results 191 to 200 of about 1,030,121 (356)

Globoid Cell Leucodystrophy (Krabbe's Disease): Deficiency of Galactocerebroside β-Galactosidase [PDF]

, 1970
Kunihiko Suzuki, Yoshiyuki Suzuki
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Uncovering Diagnostic Correlations Between Traditional Chinese and Western Medicine Using Instrumental Variable Models in Cardiometabolic Patients: Evidence from 1.2 Million Records. [PDF]

J Multidiscip Healthc
Zhou J, Zhou S, Chen H, Chen X, Zou G, Gao Y, Jing S, Bishai DM, Li J, Zhong A, Liu Z, Liu A.   +11 more
europepmc   +1 more source

SERUM CHOLINESTERASE DEFICIENCY I: DISEASE AND INHERITANCE

, 1966
George S. Robertson
openalex   +1 more source

C1r deficiency: an inborn error associated with cutaneous and renal disease [PDF]

, 1972
N K Day, Hartmut Geiger, Robert M. Stroud, M. deBracco, B. Mancado, Dorothy B. Windhorst, R. A. Good   +6 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Molecular Maestro in the Lung: The Sphingolipid Rheostat. [PDF]

Am J Respir Cell Mol Biol
Rojas-Quintero J, Polverino F.
europepmc   +1 more source

Detection of the Carrier State in Combined Immunodeficiency Disease Associated with Adenosine Deaminase Deficiency [PDF]

, 1974
C. Ronald Scott, Shi-Han Chen, Eloise R. Giblett   +2 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

T Cell-Specific Deficiency of Src Homology 2-Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation. [PDF]

MedComm (2020)
Zhang S, Ouyang Z, Fan Z, Sun H, Yu H, Wu X, Sun Y, Shao F.   +7 more
europepmc   +1 more source