Results 221 to 230 of about 563,359 (337)

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome. [PDF]

Open Med (Wars)
Kahraman FU, Demir AD, Yazıcı M, Çakır FB, Temel H, Çollak A, Erenberk U.   +6 more
europepmc   +1 more source

A Correlative Study of Hepatic Selenium Levels and Depletion Rates with the Onset of Selenium-Vitamin E Deficiency Disease in the Chick

, 1977
A. H. Rebar, John F. Van Vleet
openalex   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Association of low vitamin C concentrations and low consumption of fresh fruit and vegetables with cardiovascular disease in type 2 diabetes. [PDF]

BMC Nutr
Toffalini A, Vigolo N, Rolli N, Paviati E, Gelati M, Danese E, Zoppini G.   +6 more
europepmc   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Iodine status of pregnant women in the Chinese plateau area - effects on thyroid function as well as adverse pregnancy and fetal outcomes. [PDF]

Asia Pac J Clin Nutr
Zhao Y, Zhang Z, Chen W, Zhao R, Zhang W, Tang Z, Huang H, Huang H, Wang H.   +8 more
europepmc   +1 more source

Severe Combined Immunodeficiency Disease with Adenosine Deaminase Deficiency

, 1979
Shinkichi Yokoyama, Tadashi Hayashi, Yozo Yoshimura, Kiyoshi Irimada, Tetsu Saito, TOMOHARU AKIBA, Shigeru Tsuchiya   +6 more
openalex   +2 more sources

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

The Role of Vitamin D in Rare Diseases-A Clinical Review. [PDF]

Biomedicines
Ducki C, Wojtkiewicz M, Bartoszewicz M, Fiedor P.   +3 more
europepmc   +1 more source