Results 161 to 170 of about 6,869,765 (282)

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

The Contribution to the Assignment of Defined Daily Dose (DDD) to Antineoplastic Drugs of the Italian Working Group on DDD. [PDF]

Pharmacoepidemiol Drug Saf
Boccia A, Hyeraci G, Girardi A, Gini R, Trifirò G, Ingrasciotta Y, Spini A, Ientile V, Poluzzi E, Mazzaglia G, Antonazzo IC, Manuela C, Tragni E, Leoni O, Mazzone A, Ercolanoni M, Zanforlini M, Kirchmayer U, Valeria B, Finocchietti M, Barone-Adesi F, Roberto G.   +21 more
europepmc   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Evaluation of antibacterial agent use in adult patients at a tertiary-level hospital in Jordan: A comparative analysis of defined daily dose and days of therapy in critical care units. [PDF]

PLoS One
Hani AB, Al-Qerem W, Ashran W, Hani FB, Al-Raymoony S, Elshiekh S, Haddad M, Alsheyab Y, Alzyadat G, Khasawneh E, Heis A, Gharibeh T, Al-Shweiki R, Shahait AD.   +13 more
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Analysis of Defined Daily Dose (DDD) and antibiotic problems in Intensive Care Unit (ICU) patients. [PDF]

Explor Res Clin Soc Pharm
Yulistiani Y, Barkah HH, Utomo FN, Andrianto L, Jathi AP, Yudistira NGPR.   +5 more
europepmc   +1 more source

Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs. [PDF]

J Clin Med, 2019
Liang CM, Yang SC, Wu CK, Li YC, Yeh WS, Tai WC, Lee CH, Yang YH, Tsai TH, Hsu CN, Chuah SK.   +10 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Benchmarking Pre-National Action Plan Systemic Antimicrobial Consumption in Tanzania, 1998-2005: A Historical Longitudinal Defined Daily Dose Analysis. [PDF]

Cureus
Sangeda RZ, Kadinde AW, Khea A, Fimbo AM.   +3 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source