Results 41 to 50 of about 858,476 (293)

Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes:a substudy of the SUSTAIN 8 randomised, controlled clinical trial [PDF]

, 2020
Aims/hypothesis: Intra-abdominal or visceral obesity is associated with insulin resistance and an increased risk for cardiovascular disease. This study aimed to compare the effects of semaglutide 1.0 mg and canagliflozin 300 mg on body composition in a ...
Catarig, Andrei-Mircea, Frias, Juan P., Lausvig, Nanna L., le Roux, Carel W., Lingvay, Ildiko, McCrimmon, Rory, Thielke, Desirée   +6 more
core   +2 more sources

The lung function profile of once-daily tiotropium and olodaterol via Respimat® is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler® (ENERGITO® study) [PDF]

, 2016
Background: Tiotropium + olodaterol has demonstrated improvements beyond lung function benefits in a large Phase III clinical program as a once-daily maintenance treatment for COPD and may be a potential option for the initiation of maintenance treatment
Beeh, Kai-Michael, Bjermer, Leif,, Derom, Eric, Echave-Sustaeta, José, Grönke, Lars, Hamilton, Alan, Lund University., Lund University., Zhai, Dongmei   +8 more
core   +2 more sources

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +2 more sources

Are There Striking Differences in Outpatient Use of Antibiotics Between South Backa District, Serbia, and Some Scandinavian Countries?

Frontiers in Public Health, 2018
There is little published information about antibiotic utilization in outpatients in Serbia. The objective of this study was to determine the amount and structure of outpatient antibiotic use in South Backa District (SBD) in Serbia, to assess prescibing ...
Olga Horvat, Vesna Mijatović, Boris Milijasević, Ana Tomas, Milica Paut Kusturica, Zdenko Tomić, Ana Sabo   +6 more
doaj   +1 more source

Defined daily doses of antimicrobials reflect antimicrobial prescriptions in ambulatory care [PDF]

Journal of Antimicrobial Chemotherapy, 2004
Data on actual antimicrobial prescriptions are rarely made available and the World Health Organization (WHO) recommends using the number of defined daily doses (DDDs) as a measurement unit for inter-country comparisons of antimicrobial use in outpatients.
Dominique L, Monnet, Sigvard, Mölstad, Otto, Cars   +2 more
openaire   +2 more sources

Guidance on the Selection of Appropriate Indicators for Quantification of Antimicrobial Usage in Humans and Animals [PDF]

, 2017
An increasing variety of indicators of antimicrobial usage has become available in human and veterinary medicine, with no consensus on the most appropriate indicators to be used.
A. Hémonic, Aarestrup, Achermann, Adriaenssens, Agata, Agga, Akwar, Aldeyab, Ansari, Arnold, Ashiru-Oredope, Benedict, Bondt, Bondt, Bos, Bruyndonckx, Burow, C. Belloc, C. Chauvin, Callens, Casewell, Chantziaras, Charbonneau, Chauvin, Chauvin, Chauvin, Chauvin, Chauvin, Coenen, Collignon, Costelloe, Curtis, Dalton, De With, DeVincent, Dumartin, Dunlop, Elseviers, Ferech, Filippitzi, Filius, Fortin, Fridkin, Garcia-Migura, Goossens, Goossens, Grave, Grave, Grohskopf, Hammerum, Hoffman, Hunter, Huttner, J. Dewulf, Jacquet, Jensen, Jensen, Jensen, K. D. C. Stärk, Kardas, Kern, Kritsotakis, Kuster, L. Collineau, Laanen, Levy, Lewis, M. Postma, Merle, Meyer, Meyer, Monnet, Monnet, Moreno, Muller, Mölstad, Pardon, Persoons, Persoons, Petrov, Polk, Postma, Resi, Schwartz, Simoneit, Stege, Suda, Sun, Swinkels, Taverne, Taylor, Thrusfield, Timmerman, Vaarten, Van de Sande-Bruinsma, Vander Stichele, Varga, Versporten, Weese, Wierup, Wirtz   +100 more
core   +4 more sources

Reforming the Swedish pharmaceuticals market: consequences for costs per defined daily dose [PDF]

International Journal of Health Economics and Management, 2016
In 2009 and 2010, the Swedish pharmaceuticals market was reformed. One of the stated policy goals was to achieve low costs for pharmaceutical products dispensed in Sweden. We use price and sales data for off-patent brand-name and generic pharmaceuticals to estimate a log-linear regression model, allowing us to assess how the policy changes affected the
Bergman, Mats, Granlund, David, Rudholm, Niklas   +2 more
openaire   +3 more sources

Three-year outcomes of a once daily fractionation scheme for accelerated partial breast irradiation (APBI) using 3-D conformal radiotherapy (3D-CRT). [PDF]

, 2013
The aim of this study was to report 3-year outcomes of toxicity, cosmesis, and local control using a once daily fractionation scheme (49.95 Gy in 3.33 Gy once daily fractions) for accelerated partial breast irradiation (APBI) using three-dimensional ...
Daroui, Parima, Goyal, Sharad, Haffty, Bruce G, Kearney, Thomas, Khan, Atif J, Kirstein, Laurie   +5 more
core   +2 more sources

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver, Blyth, Kevin G., De Fonseka, Duneesha, Edey, Anthony, Lee, Y. C. Gary, Martin, Geoffrey, Maskell, Nick, Piccolo, Francesco, Popowicz, Natalia, Smith, Nicola A., Wong, Donny   +10 more
core   +1 more source

Outpatient Antibiotic Prescriptions in Pregnant Women in Małopolska Province

Antibiotics, 2020
Background: excessive and incorrect use of antibiotics is a common event that contributes to increased bacterial resistance to antibiotics. Based on the European Centre for Disease Control and Prevention (ECDC) European Surveillance of Antimicrobial ...
Anna Różańska, Agnieszka Pac, Estera Jachowicz, Dorota Jaślan, Małgorzata Siewierska, Jadwiga Wójkowska-Mach   +5 more
doaj   +1 more source