Results 151 to 160 of about 728,595 (260)

Health promotion research involving older adults in the Nordic countries: a scoping review of doctoral theses. [PDF]

Prim Health Care Res Dev
Nivestam A, Seneca Terkelsen A, Clancy A, Lind J, Simonsen N.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Concept of premature mortality: protocol for a scoping review. [PDF]

BMJ Open
Muszyńska-Spielauer M, Paulik PF.
europepmc   +1 more source

On the Definition of Life

Philosophy Study, 2019
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Dementia risk by metabolic health and obesity in two prospective cohorts. [PDF]

BMC Med
Nakash M, Ojalehto Lindfors E, Zhan Y, Dahl Aslan AK, Reynolds CA, Ler P, Karlsson IK.   +6 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reconsidering the LARS score: a cross-sectional descriptive study exploring complementary screening approaches for low anterior resection syndrome. [PDF]

Int J Colorectal Dis
Ribas Y, Cayetano L, Ortega-Torrecilla N, Espín-Basany E, Bargalló J, Romero C, Marinello F.   +6 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

What is new in the early health technology assessment's new definition? [PDF]

Int J Technol Assess Health Care
Espinoza MA.
europepmc   +1 more source