Results 201 to 210 of about 728,595 (260)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessing flares in patients with psoriatic arthritis using questionnaires. [PDF]

RMD Open
Chronis NJ, Pereira D, Gao S, Chandran V.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Cross-national associations between adulthood stressful life events and incident heart disease: a multicohort harmonized analysis. [PDF]

Front Cardiovasc Med
Mi P, Wang H, Feng H, Kang S.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A new viewpoint on psychiatry: Supporting children's diversified "ibasho". [PDF]

PCN Rep
Sasaki T, Hirano Y.
europepmc   +1 more source

Redefining the boundary: a rationale for lowering the upper age limit for early childhood caries to 60 months. [PDF]

Front Oral Health
Foláyan MO.
europepmc   +1 more source

The importance of enworlded selfhood for understanding chronic pain-related suffering. [PDF]

Theor Med Bioeth
Svenaeus F.
europepmc   +1 more source

Four methods for estimating hepatitis C incidence using extant testing data. [PDF]

PLoS One
McFarlane WJ, Flemming JA, Brogly SB, Peng Y.   +3 more
europepmc   +1 more source

Establishing the human functioning sciences sections in frontiers in rehabilitation sciences. [PDF]

Front Rehabil Sci
Bickenbach J, Boggs D, Prodinger B, Stucki G.   +3 more
europepmc   +1 more source