Results 111 to 120 of about 3,752,035 (291)

Advancing perspectives on the off-label use of anticancer drugs: an updated classification and exploration of categories

open access: yesFrontiers in Pharmacology
To date, the definition that the off-label usage of drugs refers to the unapproved use of approved drugs, which covers unapproved indications, patient populations, doses, and/or routes of administration, has been in existence for many years.
Xiaoyi Chen   +4 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

What Is a Working Equid? Analysis of Current Terminology and a Suggested Definition

open access: yesAnimals
Equids are engaged in myriad types of work across the world, with contexts and industries varying widely between high-, middle- and low-income countries as classified by the World Bank.
Zoe Raw   +2 more
doaj   +1 more source

On the Definition of Intelligence

open access: yes
Accepted at AGI-25. Enhancing mathematical rigor and conceptual clarity. All instances of "category" and "sample" have been consistently replaced with "concept" and "entity" respectively, and the precise relationship between concepts, fibres, and entities has been refined throughout the paper for greater ...
openaire   +2 more sources

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters   +17 more
wiley   +1 more source

The AI Definition and a Program Which Satisfies This Definition

open access: yesSerdica Journal of Computing
We will consider all policies of the agent and will prove that one of them is the best performing policy. While that policy is not computable, computable policies do exist in its proximity. We will define AI as a computable policy which is sufficiently proximal to the best performing policy.
openaire   +3 more sources

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Challenges in estimating the severity of kidney dysfunction in critically ill children

open access: yesJournal of Pediatric Critical Care
Acute kidney injury (AKI) is a common problem in critical care settings and conferred an increased risk of morbidities and mortality. The pendulum has shifted to the increasing number of children with comorbidities exposed to potential kidney damage. AKI
Ramachandran Rameshkumar   +2 more
doaj   +1 more source

Learning First-Order Definitions of Functions

open access: yes, 1996
First-order learning involves finding a clause-form definition of a relation from examples of the relation and relevant background information. In this paper, a particular first-order learning system is modified to customize it for finding definitions of
Quinlan, J. R.
core   +2 more sources

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

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