Results 151 to 160 of about 364,159 (261)

Hope without certainty. [PDF]

Palliat Support Care
Shteynberg C.
europepmc   +1 more source

On the Definition of Life

Philosophy Study, 2019
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Recommendations for studying the safety, efficacy and durability of intracranial aneurysm devices. [PDF]

Eur Stroke J
Volovici V, Meling TR, Krings T, Taussky P, Collins GS, Rinkel GJE, Vergouwen MDI.   +6 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Postoperative Bleeding Definitions as the Foundation of Hemostasis in Pediatric Cardiac Surgery. [PDF]

Diagnostics (Basel)
Karam O, Atchison C, Chegondi M.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Clarifying Baseline Cognitive Eligibility and Cross-Scale Follow-Up in a Randomized Trial of Remimazolam Tosylate for Laparoscopic Surgery [Response To Letter]. [PDF]

Drug Des Devel Ther
Liu J, Li M, Wang H, Wang S.
europepmc   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Testing and evaluating updated variants of the rurality index for Japan: a nationwide methodological study. [PDF]

BMJ Open
Kaneko M, Ikeda T, Shimizu S, Sato T, Nomura O, Soma Y, Inoue M, Ishikawa KB, Matsuda S.   +8 more
europepmc   +1 more source