Results 61 to 70 of about 403 (117)

Effects of racemic anisodamine in combination with orthokeratology and defocus incorporated multiple segment spectacle lenses for myopia control in adolescents

Scientific Reports
This study aimed to evaluate the clinical application of different myopia correction methods in the prevention and control of myopia in adolescents. A total of 145 myopic adolescents aged 8 to 15 years were included, and their eyes were divided into four
Yi Deng, Jie Gao, Yu Mei, Wen-Jing Ran
doaj   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

An unattended image‐processing pipeline for on‐the‐fly quality assessment and 3D exploration in cryo‐EM

Acta Crystallographica Section D, Volume 82, Issue 8, Page 915-939, August 2026.
We present a fully automated, unattended cryo‐EM pipeline that serves as an on‐the‐fly diagnostic tool, enabling rapid data‐quality assessment and informed decision‐making to maximize data‐collection efficiency.Single‐particle analysis (SPA) by cryogenic electron microscopy (cryo‐EM) has become a cornerstone of structural biology; yet, the workflow ...
Daniel Marchán Torres, Pablo Conesa, Alberto Garcia, Mikel Iceta, Ludovic Broche, Marcos Gragera, Romain Linares, Hok Sau Kwong, Francisco Javier Chichón, Olof Svensson, Rocío Arranz, Grégory Effantin, Eaazhisai Kandiah, José María Carazo, Carlos O. S. Sorzano   +14 more
wiley   +1 more source

Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment

BMJ Open Ophthalmology
Objective To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters
Christof Meigen, Adrienne Csutak, Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy   +7 more
doaj   +1 more source

Helical reconstruction of amyloids in cryoSPARC

Acta Crystallographica Section F, Volume 82, Issue 7, Page 252-261, July 2026.
We present practical guidelines for helical reconstruction of amyloid filaments in cryoSPARC, benchmarked against publicly available datasets. Our analysis defines current capabilities and limitations, and outlines optimization strategies to enable high‐throughput structural studies and therapeutic discovery.Amyloid‐mediated proteotoxicity underlies ...
Jan-Hannes Schaefer, Robert T. O'Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander   +5 more
wiley   +1 more source

Assessment of binocular vision and accommodation in myopic children wearing Defocus Incorporated Multiple Segments (DIMS) Lenses for 24 Months

Abstract Purpose: The study aimed to investigate the changes in binocular vision (BV) and accommodation in myopic children following long-term wear of Defocus Incorporated Multiple Segments (DIMS) spectacle lenses for 24 months. Methods: Twenty-three Malay myopic children aged 7–12 years were enrolled in this prospective, self-controlled study.
Nur Adibah Yahaya, Fatin Nur Najwa Norazman, Bariah Mohd-Ali, Mizhanim Mohamad Shahimin, Norliza Mohamad Fadzil   +4 more
openaire   +1 more source

From Nominalisation to Passive in Old Tibetan: Reconstructing Grammatical Meaning in an Extinct Language

Transactions of the Philological Society, Volume 124, Issue 2, Page 314-356, July 2026.
Abstract Based on an analysis of the Old Literary Tibetan corpus—a corpus of the oldest documented Tibetic language—the present study provides evidence that literary Tibetan v3 verb stems (commonly termed ‘future’) initially encoded passive voice. New arguments put forward in this article range from Trans‐Himalayan nominal morphology to early Tibetan ...
Joanna Bialek
wiley   +1 more source

Comprehensive Biophysical Profiling Evidences Self‐Oligomerization of Bacterially Expressed Pc Protein

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid, Sabin Prajapati, Ghazaleh Alamdari, Kai Tittmann, Selin Kara   +4 more
wiley   +1 more source

Association between myopia progression and cylinder power progression in defocus incorporated multiple segments lens wearers

Scientific Reports
The aim of this study was to explore the correlation between the parameters associated with the prevention and management of myopia and cylinder power (CP) progression in individuals who wear defocus incorporated multiple segments (DIMS) lenses. In total,
Ling Wang, Qing Zhang, Tingting Zhou, Wenli Yu, Jincheng Wang, Ran Li, Qin Chen, Qingbo Que, Xiaomin Gao   +8 more
doaj   +1 more source

Additional file 1 of Evaluating the myopia progression control efficacy of defocus incorporated multiple segments (DIMS) lenses and Apollo progressive addition spectacle lenses (PALs) in 6- to 12-year-old children: study protocol for a prospective, multicenter, randomized controlled trial

, 2020
Additional file 1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents.
Li, Yan, Fu, Yafei, Wang, Kai, Liu, Zhiming, Shi, Xiaoqing, Zhao, Mingwei   +5 more
openaire   +1 more source