Results 61 to 70 of about 5,241 (151)

Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease

open access: yesNeuroImage, 2008
Magnetic resonance imaging (MRI) of transgenic mice has the potential to provide valuable insight into the complex mechanisms underlying Alzheimer's disease (AD). Quantification of pathological changes is typically performed using manual segmentation methods, and requires a priori hypotheses about anatomical structures for volumetric measurement ...
Jonathan C. Lau   +5 more
openaire   +2 more sources

C.03 Deformation-based morphometry analysis of longitudinal low-grade glioma growth [PDF]

open access: yesCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2019
Background: Diffuse low-grade gliomas (LGGs) are primary brain tumours with infiltrative, anisotropic growth related to surrounding white and grey matter structures. Deformation-based morphometry (DBM) is a simple and objective image analysis method that can identify areas of local volume change over time. In this study, we illustrate the use of DBM to
C Gui   +4 more
openaire   +1 more source

Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long‐duration spaceflight

open access: yesExperimental Physiology, EarlyView.
Abstract Long‐duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight‐associated neuro‐ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions.
Ge Tang   +19 more
wiley   +1 more source

Visualizing the neuroanatomical changes in Han Chinese adulthood: A pseudo-longitudinal study based on age-related large-scale statistical Chinese brain atlases

open access: yesBrain Science Advances, 2019
Objective: Understanding how brain changes over lifetime provides the basis for new insights into neurophysiology and neuropathology. In this study, we carried out a pseudo-longitudinal study based on age-related Chinese brain atlases (i.e., Chinese2020)
Lin Shi   +7 more
doaj   +1 more source

Clinical and research applications of synthetic bone substitutes in equine veterinary medicine: A systematic review

open access: yesEquine Veterinary Journal, Volume 58, Issue 5, Page 1150-1168, September 2026.
Abstract Background Bone grafting in equine medicine offers a promising contribution to treating orthopaedic developmental diseases and chondral, osteochondral and segmental bone defects. Among grafts, synthetic bone substitutes—alloplastics—show favourable biological properties addressing numerous limitations presented by autografts, xenografts and ...
Katarzyna Skierbiszewska   +6 more
wiley   +1 more source

An in vivo MRI template set for morphometry, tissue segmentation and fMRI localization in rats

open access: yesFrontiers in Neuroinformatics, 2011
Over the last decade, several papers have focused on the construction of highly detailed mouse high field MRI templates via nonlinear registration to unbiased reference spaces, allowing for a variety of neuroimaging applications such as robust ...
Pedro Antonio Valdes Hernandez   +8 more
doaj   +1 more source

The neuropsychological impact of early childhood trauma on cognitive development: A narrative review of mechanisms, outcomes, and interventions

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Research indicates that early traumatic experiences can profoundly affect a child's ability to manage emotions, develop social skills, and adapt effectively. Still, the impact of trauma on children goes beyond just emotional and behavioral dimensions.
Kalliopi Megari, Kremena Dinkova Genova
wiley   +1 more source

Artificial intelligence‐based statistical modeling delineates architectural distortion in focal cortical dysplasia

open access: yesBrain Pathology, Volume 36, Issue 5, September 2026.
Histopathological identification of subtle cortical architectural abnormalities in focal cortical dysplasia (FCD) resections remains challenging. We investigated if artificial intelligence (AI)‐based morphometric and spatial analysis of NeuN‐stained cortical sections could detect neuronal architectural disorganization in epilepsy resections, including ...
Andrew Cannon   +9 more
wiley   +1 more source

A Discovery and Replication Study of Dyslexia Does Not Reveal Reproducible Gray Matter Volume Differences

open access: yesHuman Brain Mapping, Volume 47, Issue 11, 01 August 2026.
This study shows that gray matter volume (GMV) differences in dyslexia fail to replicate across two studies in large, representative samples, and reproducibility of results is dependent on analytic choices, particularly whether total GMV is accounted for. Prior GMV findings in dyslexia should therefore be considered with caution.
Alison K. Schug   +2 more
wiley   +1 more source

Altered Cortical Morphological Brain Networks and Their Diagnostic Classification Utility in Major Depressive Disorder

open access: yesHuman Brain Mapping, Volume 47, Issue 11, 01 August 2026.
Using structural MRI data from over 2700 participants, this large‐scale study shows that major depressive disorder exhibits distinct, feature‐specific alterations across multiple brain structural networks. These changes are already present in first‐episode, drug‐naive patients and allow effective differentiation between individuals with depression and ...
Xuetian Sun   +129 more
wiley   +1 more source

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