Results 61 to 70 of about 23,783,590 (301)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

ANALYSIS ON q-DEFORMED QUANTUM SPACES [PDF]

open access: yesInternational Journal of Modern Physics A, 2007
A q-deformed version of classical analysis is given to quantum spaces of physical importance, i.e. Manin plane, q-deformed Euclidean space in three or four dimensions, and q-deformed Minkowski space. The subject is presented in a rather complete and self-contained way. All relevant notions are introduced and explained in detail.
openaire   +3 more sources

Integrated analysis of rock mass deformation within shaft protective pillar [PDF]

open access: yes, 2015
The paper presents an analysis of the rock mass deformation resulting from mining in the vicinity of the shaft protection pillar. A methodology of deformation prediction is based on a deterministic method using Finite Element Method (FEM).
Warchala, E.   +3 more
core   +1 more source

Investigation on Dewatering Scheme Optimization, Water Levels, and Support Layout Influences for Steel Sheet Pile Cofferdams

open access: yesBuildings
Based on the steel sheet pile cofferdam project for the main bridge piers of a cross-sea bridge, finite element numerical simulations were conducted to analyze the influence of construction sequences in marine environments, as well as the effects of ...
Meng Xiao   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Geometrical nonlinear analysis of thin-walled composite beams using finite element method based on first order shear deformation theory [PDF]

open access: yes, 2010
Based on a seven-degree-of-freedom shear deformable beam model, a geometrical nonlinear analysis of thin-walled composite beams with arbitrary lay-ups under various types of loads is presented.
Lee, Jaehong   +3 more
core   +1 more source

Uporabnost izbranih metod deformacijske analize na praktičnih primerih geodetskih mrež : Applicability of Selected Methods of Deformation Analysis [PDF]

open access: yesGeodetski Vestnik, 2006
The basic problem in deformation analysis is detection and determination of stability or displacement of the points in the geodetic network during two epochs.
Blaž Mozetič   +2 more
doaj  

Safety Risk Analysis of a New Design of Basalt Fiber Gabion Slope Based on Improved 3D Discrete Element Method and Monitoring Data

open access: yesSensors, 2022
Gabion has been extensively used in retaining walls and slope protection. This study carries out a safety risk analysis of a new structure combining basalt fiber reinforcement (BFR) and the traditional gabion structure.
Jianjian Dai   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Deformation Analysis of Large-Scale Rock Slopes Considering the Effect of Microseismic Events

open access: yesApplied Sciences, 2019
To research the macroscopic deformation of rock microseismic damage, a high-precision microseismic monitoring system was established on the left bank slope of the Baihetan hydropower station in Southwestern China. Based on the microseismic monitoring and
Linlu Dong   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy