Results 61 to 70 of about 184,696 (315)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Compaction creep of quartz sand at 400-600°C: Experimental evidence for dissolution-controlled pressure solution

open access: yes, 2002
Intergranular pressure solution (IPS) is an important compaction and deformation mechanism in quartzose rocks, but the kinetics and rate-controlling process remain unclear. The aim of the present study is to test microphysical models for compaction creep
Spiers, C.J.   +4 more
core   +1 more source

Atomistic Investigation of Material Deformation Behavior of Polystyrene in Nanoimprint Lithography

open access: yesSurfaces, 2020
This research investigates deformation behavior of polystyrene (PS) as a thermoplastic resist material for the thermal nanoimprint lithography (T-NIL) process.
Jahlani Odujole, Salil Desai
doaj   +1 more source

Progress of titanium-based laminated materials by powder metallurgy

open access: yesFenmo yejin jishu, 2023
Based on the increasingly severe working environment, properties of titanium materials are facing the new challenges as the superior combination of strength and ductility.
XU Jingru   +5 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Deformation-Induced Phase Transformations in Gold Nanoribbons with the 4H Phase

open access: yes, 2022
The mechanical stability of metallic nanomaterials has been intensively studied due to their unique structures and promising applications. Although extensive investigations have been carried out on the deformation behaviors of metallic nanomaterials, the
Ade Kismarahardja   +21 more
core   +1 more source

Microstructure evolution and stress rupture properties of A286 superalloy in the 600 to 750 °C temperature range

open access: yesMaterials Research Express, 2021
To study the stress rupture properties of the A286 alloy in high temperature service environment, the stress rupture tests of A286 alloy at different temperature ranges and stress levels were carried out.
Li Wei   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Investigation of the mechanical response and deformation mechanism of cortical bone material under combined compression and bending loads

open access: yesMaterials Research Express, 2022
Objective service load is the load pattern of cortical bone in practical conditions. The objective service load conditions of cortical bone are complicated, usually including two or more load patterns. The mechanical behavior and deformation mechanism of
Xingdong Sun   +6 more
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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