Results 71 to 80 of about 32,140 (211)
Exaptation, Degeneracy and Innovation [PDF]
In innovation processes, exaptations are innovation-development processes through which an initial attribution of new functionality to existing artifacts leads to new artifacts and eventually new markets.
Giovanni Bonifati
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Uniqueness of solutions to a system of differential inclusions
Electronic Journal of Differential Equations, 2000 In this paper we study the uniqueness of solutions to the initial and Dirichlet boundary-value problem of differential inclusions $$ Delta u_i+ablacdotvec {B_i} (u_1,u_2,dots,u_N)in {partial F_i(u_i) over partial t}, quad i=1,2,dots,N, $$ where $vec{B_i}(
Chunpeng Wang, Jingxue Yin
doaj
eLifeNociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical ...
Yu-Feng Xie +3 more
doaj +1 more source
Filtering Statistics on Networks
Entropy, 2020 Compression, filtering, and cryptography, as well as the sampling of complex systems, can be seen as processing information. A large initial configuration or input space is nontrivially mapped to a smaller set of output or final states.
G. J. Baxter +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source
BioTechniquesReproducibility in antibody discovery is undermined by dropout, paratope degeneracy, and immunogen imprinting. Although guidelines exist, the field lacks a shared, assay-locked metric to benchmark these liabilities across discovery pipelines.
Michael P. Weiner
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Heritability of types of a pregeometry relative to a family of relational structures
Қарағанды университетінің хабаршысы. Математика сериясыA series of geometrical and topological properties induced by structures, including degeneration, modularity, local modularity, projectivity, local finiteness, etc., play an important role in clarifying structural relationships and in classifying basic ...
S.B. Malyshev, S.V. Sudoplatov
doaj +1 more source
eLife, 2014 Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté +3 more
doaj +1 more source