Results 61 to 70 of about 54,906 (291)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Device-independent certification of degeneracy-breaking measurements [PDF]

, 2023
In a device-independent Bell test, the devices are considered to be black boxes and the dimension of the system remains unspecified. The dichotomic observables involved in such a Bell test can be degenerate and one may invoke a suitable measurement ...
Pan, Alok Kumar
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A Note on Contraction Degeneracy

, 2004
The parameter contraction degeneracy -- the maximum minimum degree over all minors of a graph -- is a treewidth lower bound and was first defined in (Bodlaender, Koster, Wolle, 2004).
Wolle, Thomas, Koster, Arie M.C.A., Bodlaender, Hans L.   +2 more
core   +2 more sources

Degeneracy and long-range correlations [PDF]

, 2013
Degeneracy is a ubiquitous property of complex adaptive systems, which refers to the ability of structurally different components to perform the same function in some conditions and different functions in other conditions.
Delignières, D., Marmelat, Vivien
core   +1 more source

Degeneracy in the Blasius problem

Electronic Journal of Differential Equations, 2007
The Navier-Stokes equations for the boundary layer are transformed, by a similarity transformation, into the ordinary Blasius differential equation which, together with appropriate boundary conditions constitutes the Blasius problem, $$ f'''(
Faiz Ahmad
doaj  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Sharp viscous shock waves for relaxation model with degeneracy

Advances in Nonlinear Analysis
This article is concerned with a relaxation model with degeneracy. Different from the existing studies on the regular viscous shock waves, we recognize that when the sub-characteristic condition is degenerate, the dynamical system possesses sharp viscous
Xu Shufang, Mei Ming, Sheng Wancheng, Wang Zejia   +3 more
doaj   +1 more source

Postoptimal analysis in the coefficients matrix of piecewise linear fractional programming problems with non-degenerate optimal solution [PDF]

Opuscula Mathematica, 2010
In this paper, we discuss how changes in the coefficients matrix of piecewise linear fractional programming problems affect the non-degenerate optimal solution.
Behrouz Kheirfam
doaj   +1 more source