Results 71 to 80 of about 55,044 (293)

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

Uniqueness of solutions to a system of differential inclusions

open access: yesElectronic Journal of Differential Equations, 2000
In this paper we study the uniqueness of solutions to the initial and Dirichlet boundary-value problem of differential inclusions $$ Delta u_i+ablacdotvec {B_i} (u_1,u_2,dots,u_N)in {partial F_i(u_i) over partial t}, quad i=1,2,dots,N, $$ where $vec{B_i}(
Chunpeng Wang, Jingxue Yin
doaj  

Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

open access: yeseLife
Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical ...
Yu-Feng Xie   +3 more
doaj   +1 more source

Filtering Statistics on Networks

open access: yesEntropy, 2020
Compression, filtering, and cryptography, as well as the sampling of complex systems, can be seen as processing information. A large initial configuration or input space is nontrivially mapped to a smaller set of output or final states.
G. J. Baxter   +3 more
doaj   +1 more source

Balinski-Tucker simplex tableaus : dimensions, degeneracy degrees, and interior points of optimal faces [PDF]

open access: yes
This paper introduces a general, formal treatment of dynamic constraints, i.e., constraints on the state changes that are allowed in a given state space.
Tijssen, Gert A., Sierksma, Gerard
core  

Degeneracy in Heteroscedastic Regression Models [PDF]

open access: yes, 2000
The maximum likelihood estimation in a regression model with heteroscedastic errors is considered. When the design matrices in the model are inappropriately specified, the maximum likelihood estimates of the variances of certain observations are found to
Chan, Nai Ng, Li, Kim-Hung
core   +1 more source

Tsallis Entropy and Degeneracy

open access: yes, 2023
For a Maxwell-Boltzmann situation, one may consider the number of permutations of N particles with n(ei) of them having energy ei i.e. N!/ Product over i n(ei)!. In such a case, n(ei)! removes the degeneracy of the identical n(ei) particles.
Francesco R. Ruggeri
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Benchmarking antibody discovery fidelity and reproducibility with an assay-locked residue fidelity index

open access: yesBioTechniques
Reproducibility in antibody discovery is undermined by dropout, paratope degeneracy, and immunogen imprinting. Although guidelines exist, the field lacks a shared, assay-locked metric to benchmark these liabilities across discovery pipelines.
Michael P. Weiner
doaj   +1 more source

Exaptation, Degeneracy and Innovation [PDF]

open access: yes
In innovation processes, exaptations are innovation-development processes through which an initial attribution of new functionality to existing artifacts leads to new artifacts and eventually new markets.
Giovanni Bonifati
core  

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