Results 51 to 60 of about 11,801 (293)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sharp forced waves of degenerate diffusion equations in shifting environments

Advances in Nonlinear Analysis
This article is concerned with the sharp forced waves for degenerate diffusion equations in a shifting environment. The degeneracy of diffusion usually causes the forced waves to become sharp.
Mei Ming, Ji Shanming, Wang Zejia, Xu Tianyuan, Yin Jingxue   +4 more
doaj   +1 more source

Dynamic properties of a discrete population model with diffusion

Advances in Difference Equations, 2020
We study the dynamical properties of a discrete population model with diffusion. We survey the transcritical, pitchfork, and flip bifurcations of nonhyperbolic fixed points by using the center manifold theorem.
Ming-Shan Li, Xiao-Liang Zhou, Jiang-Ming Xu   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Martingale representation for degenerate diffusions [PDF]

Journal of Functional Analysis, 2019
Let $(W,H, )$ be the classical Wiener space on $\R^d$. Assume that $X=(X_t)$ is a diffusion process satisfying the stochastic differential equation $dX_t= (t,X)dB_t+b(t,X)dt$, where $ :[0,1]\times C([0,1],\R^n)\to \R^n\otimes \R^d$, $b:[0,1]\times C([0,1],\R^n)\to \R^n$, $B$ is an $\R^d$-valued Brownian motion. We suppose that the weak uniqueness of
openaire   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

On a hyperbolic Keller-Segel system with degenerate nonlinear fractional diffusion

Networks and Heterogeneous Media, 2016
We investigate a Keller-Segel model with quorum sensing anda fractional diffusion operator. This model describes thecollective cell movement due to chemical sensing with fluxlimitation for high cell densities and with anomalous mediarepresented by a ...
Kenneth H. Karlsen, Süleyman Ulusoy
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Thermal Energy Diffusion Incorporating Generalized Einstein Relation for Degenerate Semiconductors

Applied Sciences, 2017
The currently used generalized Einstein relation for degenerate semiconductors with isotropic nonparabolic energy bands produces physically improper results, as well as losing numerical accuracy for large values of nonparabolicity parameters at room ...
Jang Jyegal
doaj   +1 more source