Results 61 to 70 of about 11,024 (266)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Nonlocal degenerate reaction-diffusion equations with general nonlinear diffusion term
Electronic Journal of Differential Equations, 2014 We study a class of second-order nonlocal degenerate semilinear reaction-diffusion equations with general nonlinear diffusion term. Under a set of conditions on the general nonlinear diffusivity and nonlinear nonlocal source term, we prove global ...
Sikiru Adigun Sanni
doaj
On the Weak Characteristic Function Method for a Degenerate Parabolic Equation
Journal of Function Spaces, 2019 For a nonlinear degenerate parabolic equation, how to impose a suitable boundary value condition to ensure the well-posedness of weak solutions is a very important problem.
Huashui Zhan
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Almost Sure Stabilizability of Controlled Degenerate Diffusions
SIAM Journal on Control and Optimization, 2005 Summary: We develop a direct Lyapunov method for the almost sure open-loop stabilizability and asymptotic stabilizability of controlled degenerate diffusion processes. The infinitesimal decrease condition for a Lyapunov function is a new form of Hamilton-Jacobi-Bellman partial differential inequality of second order.
BARDI, MARTINO, CESARONI, ANNALISA
openaire +2 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Generalized Einstein relation for nonparabolic multiple energy-band degenerate semiconductors
AIP Advances, 2019 A generalized Einstein relation for electron gases of degenerate semiconductors with a system of typically two nonparabolic conduction band structures is derived and formulated in near-equilibrium condition based on using the semiclassical drift ...
Jang Jyegal
doaj +1 more source
Entire solutions for a reaction–diffusion equation with doubly degenerate nonlinearity
Advances in Difference Equations, 2018 This paper is concerned with the existence of entire solutions for a reaction–diffusion equation with doubly degenerate nonlinearity. Here the entire solutions are the classical solutions that exist for all (x,t)∈R2 $(x,t)\in \mathbb{R}^{2}$.
Rui Yan, Xiaocui Li
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source