Results 51 to 60 of about 11,024 (266)
Numerical analysis for the controlled degenerate chemotaxis model
BiomathThe control of chemotactic systems is a critical challenge in applied mathematics, with direct implications for biomedical applications such as cancer therapy.
Sarah Serhal +3 more
doaj +1 more source
The uniqueness of a nonlinear diffusion equation related to the p-Laplacian
Journal of Inequalities and Applications, 2018 Consider a nonlinear diffusion equation related to the p-Laplacian. Different from the usual evolutionary p-Laplacian equation, the equation is degenerate on the boundary due to the fact that the diffusion coefficient is dependent on the distance ...
Huashui Zhan
doaj +1 more source
A detour on a class of nonlocal degenerate operators
Bruno Pini Mathematical Analysis Seminar, 2023 We present some recent results on a class of degenerate operators which are modeled on the fractional Laplacian, converge to the truncated Laplacian, and are extremal among operators with fractional diffusion along subspaces of possibly different ...
Delia Schiera
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal of Inequalities and Applications, 2008 We consider the transient drift-diffusion model with fast diffusion terms. This problem is not only degenerate but also singular. We first present existence result for general nonlinear diffusivities for the Dirichlet-Neumann mixed boundary value problem.
Bin Wu
doaj +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Viscosity solutions to degenerate diffusion problems
Electronic Journal of Differential Equations, 2007 This paper concerns the weak solutions to a Cauchy problem in $R^N$ for a degenerate nonlinear parabolic equation. We obtain the Holder regularity of the weak solutions to this problem.
Zu-Chi Chen, Yan-Yan Zhao
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source