Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Enhanced phase and charge diffusion due to radio-frequency/microwave excitation in Bloch transistors
AIP Advances, 2013 Current-voltage characteristics and switching current of Bloch transistors under radio-frequency/microwave excitations were experimental studied, respectively revealing pronounced summational superconducting phase diffusion and central-island charge ...
Saxon Liou, Watson Kuo
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The uniqueness of a nonlinear diffusion equation related to the p-Laplacian
Journal of Inequalities and Applications, 2018 Consider a nonlinear diffusion equation related to the p-Laplacian. Different from the usual evolutionary p-Laplacian equation, the equation is degenerate on the boundary due to the fact that the diffusion coefficient is dependent on the distance ...
Huashui Zhan
doaj +1 more source
Degenerate Drift–Diffusion Systems for Memristors
SIAM Journal on Mathematical AnalysisA system of degenerate drift-diffusion equations for the electron, hole, and oxygen vacancy densities, coupled to the Poisson equation for the electric potential, is analyzed in a three-dimensional bounded domain with mixed Dirichlet-Neumann boundary conditions.
Ansgar Jüngel, Martin Vetter
openaire +3 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Viscosity solutions to degenerate diffusion problems
Electronic Journal of Differential Equations, 2007 This paper concerns the weak solutions to a Cauchy problem in $R^N$ for a degenerate nonlinear parabolic equation. We obtain the Holder regularity of the weak solutions to this problem.
Zu-Chi Chen, Yan-Yan Zhao
doaj
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Exponential convergence to equilibrium for coupled systems of nonlinear degenerate drift diffusion equations [PDF]
, 2021 Lisa Beck, Daniel Matthes, Martina Zizza
openalex +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source