Results 161 to 170 of about 1,208 (288)

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

A note on integrated local energy decay estimates for spherically symmetric black hole spacetimes. [PDF]

Math Ann
Holzegel G, Mavrogiannis G, Ruiz RV.
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Dynamical analysis and soliton solutions to (3+1)-dimensional extended quantum nonlinear Zakharov-Kuznetsov equation. [PDF]

Sci Rep
Fatima M, Abbas M, Higazy M, Anwar MN, Yousaf MZ, Birhanu A, Hamed YS.   +6 more
europepmc   +1 more source

Layer‐Dependent Phonon Polaritons in hBN Resolved by Photo‐Induced Force Spectroscopy

Advanced Science, EarlyView.
Layer‐dependent phonon polariton resonances in hexagonal boron nitride are systematically investigated using photo‐induced force microscopy. The in‐plane resonance exhibits a blueshift, while the out‐of‐plane resonance shows a redshift with increasing thickness. These results establish layer number as a key parameter for tuning polaritonic responses in
Amin Hajarian, Jiwoo Seo, SungWoo Nam
wiley   +1 more source

Framework for X-ray mirror surface shape fitting. [PDF]

J Synchrotron Radiat
Huang L, Xu R, Wang T, Yamada J, Dvorak J, Austin C, Eeckhout AV, Roman JN, Goldberg K, Idir M.   +9 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Sub pico-second pulses in mono-mode optical fibers with Triki-Biswas model. [PDF]

Sci Rep
Hussain A, Ibrahim TF, Alanazi FD, Rahimzai AA, Dawood AA, Osman WM.   +5 more
europepmc   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Well-posedness of the Cauchy problem for some degenerate hyperbolic operators

, 2006
We use an uniform approach to different kinds of degenerate hyperbolic Cauchy problems to prove well-posedness in C^1 and in Gevrey classes. We prove in particular that we can treat by the same method a weakly hyperbolic problem, satisfying an ...
CICOGNANI, MASSIMO, Cicognani M., A. Ascanelli, ASCANELLI, Alessia   +3 more
core