Results 51 to 60 of about 34,900 (279)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Kirchhoff equations in generalized Gevrey spaces: local existence, global existence, uniqueness [PDF]

open access: yes, 2009
In this note we present some recent results for Kirchhoff equations in generalized Gevrey spaces. We show that these spaces are the natural framework where classical results can be unified and extended.
Ghisi, Marina, Gobbino, Massimo
core   +2 more sources

Mixed problems for degenerate hyperbolic equations

open access: yesKyoto Journal of Mathematics, 1983
The author defines boundary conditions satisfying uniform Lopatinski conditions for a degenerate hyperbolic mixed problem to be an \(H^{\infty}\)-well posed mixed problem. The method is based on energy inequalities for such mixed problems, which are analogous to those in the non-degenerate case, except for having some degenerate orders. Main difference
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

ON INITIAL BOUNDARY VALUE PROBLEMS FOR THE DEGENERATE 1D WAVE EQUATION

open access: yesJournal of Optimization, Differential Equations and Their Applications, 2019
Initial boundary value problems in space-time rectangle for the following linear inhomogeneous degenerate wave equation of the second order smooth coefficient function a(x) vanishes in single points of segment.
Vladimir V. Borsch
doaj   +1 more source

Principal Symbol of Euler-Lagrange Operators

open access: yes, 2016
We shall introduce the principal symbol for Euler-Lagrange operators and use them to charac- terise well-posed initial value problems. We shall clarify how constraints can arise in Lagrangian covariant theories by extending the standard treatment in GR ...
Fatibene, Lorenzo, Garruto, Simon
core   +1 more source

$L^1$ contraction for bounded (non-integrable) solutions of degenerate parabolic equations [PDF]

open access: yes, 2014
We obtain new $L^1$ contraction results for bounded entropy solutions of Cauchy problems for degenerate parabolic equations. The equations we consider have possibly strongly degenerate local or non-local diffusion terms.
Endal, J., Jakobsen, E. R.
core   +3 more sources

An energy analysis of degenerate hyperbolic partial differential equations. [PDF]

open access: yesApplications of Mathematics, 1984
From author's summary: An energy analysis is carried out for the usual semi-discrete Galerkin method for the semilinear equation in the region \(\Omega\) : \((tu_ t)_ t=\sum_{i,j=1}(a_{ij}(x)u_{x_ i})x_ i- a_ 0(x)u+f(u),\) subject to the initial and boundary conditions, \(u=0\) on \(\partial \Omega\) and \(u(x,0)=u_ 0\).
openaire   +1 more source

Initial-boundary value problems for degenerate hyperbolic equations

open access: yesSibirskie Elektronnye Matematicheskie Izvestiya, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

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