Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi +3 more
wiley +1 more source
Simultaneous Numerical Determination of Two Time-dependent Coefficients in Second Order Parabolic Equation With Nonlocal Initial and Boundary Conditions. [PDF]
A J Al-Shatrah M, Sabah Hussein M.
europepmc +1 more source
Interaction-induced magnetotransport in a 2D Dirac-Heavy hole hybrid band system. [PDF]
Gusev GM +4 more
europepmc +1 more source
Existence of global finite-time bounded entropy solutions to a parabolic-parabolic system proposed in [16] is established in bounded domains under no-flux boundary conditions for nonnegative bounded initial data. This modification of the classical Keller-Segel model features degenerate diffusion and chemotaxis that are both subject to flux-saturation ...
openaire +4 more sources
Phase Space Electronic Structure Theory: From Diatomic Lambda-Doubling to Macroscopic Einstein-de Haas. [PDF]
Peng L +7 more
europepmc +1 more source
ABSTRACT The rate of a heterogeneous catalytic process may simultaneously be described by several rate equations. In this case, discrimination between the plausible kinetic models is required. An intrinsic kinetic model of a heterogeneous catalytic process may successively be discriminated by the transition from a reaction rate‐limited regime to an ...
Oleksii Zhokh +2 more
wiley +1 more source
Multiscale Modelling, Analysis and Simulation of Cancer Invasion Mediated by Bound and Soluble Enzymes. [PDF]
Ptashnyk M, Venkataraman C.
europepmc +1 more source
Emergent Spin Hall Quantization and High‐Order van Hove singularities in Square‐Octagonal MA2Z4
Square‐octagonal MA2Z4 (M = Mo/W, A = Si/Ge, Z = pnictogen) monolayers are predicted to realize quantum spin Hall insulators with nearly quantized spin Hall conductivity enabled by an emergent spin U(1) quasi‐symmetry. Materials with Z = As and Sb host quasi‐flat bands with high‐order van Hove singularities near the Fermi level, making them promising ...
Rahul Verma +3 more
wiley +1 more source
Orbital-selective band engineering realizes high zT in p-type Ru<sub>2</sub>Ti<sub>1-x</sub>Hf<sub>x</sub>Si full-Heusler thermoelectrics. [PDF]
Garmroudi F +6 more
europepmc +1 more source

