Results 201 to 210 of about 1,369,784 (332)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative MRI, Radiological, Histological, Biochemical, and Biomechanical Assessments. [PDF]

JOR Spine
Yusuf Y, Abbott RE, Buko EO, Chase KL, Falck AL, Pendleton D, McDermott KA, Armstrong AR, Bradley EW, Johnson CP, Ellingson AM.   +10 more
europepmc   +1 more source

Autologous Induced Stem‐Cell–Derived Retinal Cells for Macular Degeneration: Brief Report

New England Journal of Medicine, 2017
M. Mandai, Akira Watanabe, Y. Kurimoto, Y. Hirami, C. Morinaga, T. Daimon, M. Fujihara, H. Akimaru, Noriko Sakai, Yumiko Shibata, Motoki Terada, Yui Nomiya, Shigeki Tanishima, Masahiro Nakamura, H. Kamao, S. Sugita, A. Onishi, Tomoko Ito, Kanako Fujita, S. Kawamata, Masahiro J. Go, Chikara Shinohara, K. Hata, M. Sawada, Midori Yamamoto, Sachiko Ohta, Y. Ohara, Kenichi Yoshida, J. Kuwahara, Yuko Kitano, Naoki Amano, Masafumi Umekage, Fumiyo Kitaoka, Azusa Tanaka, Chihiro Okada, Naoko Takasu, S. Ogawa, S. Yamanaka, Masayo Takahashi   +38 more
semanticscholar   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Mediated Ferritinophagy Through Dual Antioxidant and Anti-Inflammatory Effects. [PDF]

Drug Des Devel Ther
Song C, Wu X, Chen C, Shen B, He Y, Liu F, Chen F, Fu Z, Liu Z.   +8 more
europepmc   +1 more source

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.

Progress in retinal and eye research, 2017
Sayantan Datta, M. Cano, K. Ebrahimi, Lei Wang, J. Handa   +4 more
semanticscholar   +1 more source

Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony‐Forming Cells

Advanced Healthcare Materials, EarlyView.
A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level, Marc‐Antoine Campeau, Mohamed A. Elkhodiry, Gaétan Laroche, Jean‐François Tanguay, Corinne A. Hoesli   +5 more
wiley   +1 more source

Role of cytokines in intervertebral disc degeneration: pain and disc content

Nature Reviews Rheumatology, 2014
M. Risbud, I. Shapiro
semanticscholar   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Loss of Kv8.2 in the Mouse Retina Is Associated With Altered One-Carbon Metabolism. [PDF]

J Neurochem
Kruth K, Baker SA.
europepmc   +1 more source